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  Clonal expansions of CD8(+) T cells in latently HSV-1-infected human trigeminal ganglia

Held, K., Eiglmeier, I., Himmelein, S., Sinicina, I., Brandt, T., Theil, D., et al. (2012). Clonal expansions of CD8(+) T cells in latently HSV-1-infected human trigeminal ganglia. JOURNAL OF NEUROVIROLOGY, 18(1), 62-68. doi:10.1007/s13365-011-0067-9.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-9CFA-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-9CFB-4
Genre: Journal Article

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 Creators:
Held, Kathrin1, Author              
Eiglmeier, Ingrid1, Author              
Himmelein, Susanne2, Author
Sinicina, Inga2, Author
Brandt, Thomas2, Author
Theil, Diethilde2, Author
Dornmair, Klaus1, Author              
Derfuss, Tobias2, Author
Affiliations:
1Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society, ou_1113547              
2External Organizations, ou_persistent22              

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Free keywords: HERPES-SIMPLEX-VIRUS; MULTIPLE-SCLEROSIS; SENSORY GANGLIA; OLIGOCLONALITY; INFECTION; PERSIST; TUMORHSV-1; Latency; CD8(+) T cells; Human; Trigeminal ganglia;
 Abstract: Herpes simplex virus type 1 latency in trigeminal ganglia (TG) is accompanied by a chronic immune cell infiltration. The aim of this study was to analyse the T-cell receptor beta-chain repertoire in latently HSV-1 infected human TG. Using complementarity-determining region 3 spectratyping, 74 expanded beta-chain sequences were identified in five TG. No clone appeared in more than one subject. Similar clones were present in the right and the left TG of two subjects. This indicates that these T cells are primed in the periphery and recognise the same antigen in the TG of both sides.

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Language(s): eng - English
 Dates: 2012-02
 Publication Status: Published in print
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: ISI: 000302246800007
DOI: 10.1007/s13365-011-0067-9
 Degree: -

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Title: JOURNAL OF NEUROVIROLOGY
Source Genre: Journal
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Publ. Info: 233 SPRING ST, NEW YORK, NY 10013 USA : SPRINGER
Pages: - Volume / Issue: 18 (1) Sequence Number: - Start / End Page: 62 - 68 Identifier: ISSN: 1355-0284