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  Bioinorganic chemistry of copper coordination to alpha-synuclein: relevance to Parkinson's disease.

Binolfi, A., Quintanar, L., Bertoncini, C. W., Griesinger, C., & Fernandez, C. O. (2012). Bioinorganic chemistry of copper coordination to alpha-synuclein: relevance to Parkinson's disease. Coordination Chemistry Reviews, 256(19-20), 2188-2201. doi:10.1016/j.ccr.2012.05.004.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-9E77-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-2551-1
Genre: Journal Article

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Binolfi, A., Author
Quintanar, L., Author
Bertoncini, C. W., Author
Griesinger, C.1, Author              
Fernandez, C. O.1, Author              
Affiliations:
1Department of NMR Based Structural Biology, MPI for biophysical chemistry, Max Planck Society, ou_578567              

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Free keywords: Alpha-synuclein; Copper; Coordination chemistry; Oxidative damage; Neurodegeneration
 Abstract: Alpha-synuclein (AS) aggregation is associated with neurodegeneration in Parkinson'sdisease (PD). At the same time, alterations in metal ion homeostasis may play a pivotal role in the progression of AS amyloid assembly and the onset of PD. Elucidation of the structural basis directing AS–metal interactions and their effect on AS aggregation constitutes a key step toward understanding the role of metal ions in AS amyloid formation and neurodegeneration. This work provides a comprehensive review of recent advances attained in the bioinorganic chemistry of AS amyloid diseases. A hierarchy in AS–metal ion interactions has been established: while the physiologically relevant divalent metal ions iron and manganese interact at a non-specific, low-affinity binding interface in the C-terminus of AS, copper binds with high affinity at the N-terminal region and it is the most effective metal ion in accelerating AS filament assembly. The strong link between metal binding specificity and its impact on aggregation is discussed here on a mechanistic basis. A detailed description of the structural features and coordination environments of copper to AS is presented and discussed in the context of oxidative cellular events that might lead to the development of PD. Overall, the research observations presented here support the notion that perturbations in copper metabolism may be a common upstream event in the pathogenesis of neurodegenerative processes.

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Language(s): eng - English
 Dates: 2012-05-142012-10
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.ccr.2012.05.004
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Title: Coordination Chemistry Reviews
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Source Genre: Journal
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Pages: - Volume / Issue: 256 (19-20) Sequence Number: - Start / End Page: 2188 - 2201 Identifier: -