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  Scatter-based magnetic resonance elastography

Papazoglou, S., Xu, C., Hamhaber, U., Siebert, E., Bohner, G., Klingebiel, R., et al. (2009). Scatter-based magnetic resonance elastography. Physics in Medicine and Biology, 54(7), 2229-2241. doi:10.1088/0031-9155/54/7/025.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-A007-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-FA9E-3
Genre: Journal Article

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Papazoglou, Sebastian1, Author
Xu, Chao1, Author              
Hamhaber, Uwe1, Author
Siebert, Eberhard1, Author
Bohner, Georg1, Author
Klingebiel, Randolf1, Author
Braun, Jürgen1, Author
Sack, Ingolf1, Author
Affiliations:
1Department of Radiology, Charité-Universitätsmedizin Berlin, Campus Mitte, Charitéplatz 1, 10117 Berlin, Germany, ou_persistent22              

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 Abstract: Elasticity is a sensitive measure of the microstructural constitution of soft biological tissues and increasingly used in diagnostic imaging. Magnetic resonance elastography (MRE) uniquely allows in vivo measurement of the shear elasticity of brain tissue. However, the spatial resolution of MRE is inherently limited as the transformation of shear wave patterns into elasticity maps requires the solution of inverse problems. Therefore, an MRE method is introduced that avoids inversion and instead exploits shear wave scattering at elastic interfaces between anatomical regions of different shear compliance. This compliance-weighted imaging (CWI) method can be used to evaluate the mechanical consistency of cerebral lesions or to measure relative stiffness differences between anatomical subregions of the brain. It is demonstrated that CWI-MRE is sensitive enough to reveal significant elasticity variations within inner brain parenchyma: the caudate nucleus (head) was stiffer than the lentiform nucleus and the thalamus by factors of 1.3 ± 0.1 and 1.7 ± 0.2, respectively (P < 0.001). CWI-MRE provides a unique method for characterizing brain tissue by identifying local stiffness variations.

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 Dates: 2009-01-282008-10-162009-03-172009-04-07
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1088/0031-9155/54/7/025
 Degree: -

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Title: Physics in Medicine and Biology
  Other : Phys. Med. Biol.
Source Genre: Journal
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Publ. Info: London : IOP Pub.
Pages: - Volume / Issue: 54 (7) Sequence Number: - Start / End Page: 2229 - 2241 Identifier: ISSN: 0031-9155
CoNE: https://pure.mpg.de/cone/journals/resource/954925433410