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  Real-time phase-contrast MRI of cardiovascular blood flow using undersampled radial fast low-angle shot and nonlinear inverse reconstruction.

Joseph, A. A., Merboldt, K. D., Voit, D., Zhang, S., Uecker, M., Lotz, J., et al. (2012). Real-time phase-contrast MRI of cardiovascular blood flow using undersampled radial fast low-angle shot and nonlinear inverse reconstruction. NMR in Biomedicine, 25(7), 917-924. doi:10.1002/nbm.1812.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-A256-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-1DF5-1
Genre: Journal Article

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 Creators:
Joseph, A. A.1, Author              
Merboldt, K. D.1, Author              
Voit, D.1, Author              
Zhang, S.1, Author              
Uecker, M.1, Author              
Lotz, J., Author
Frahm, J.1, Author              
Affiliations:
1Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society, ou_578634              

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Free keywords: Cardiovascular MRI; flow imaging; heart function; nonlinear inverse reconstruction; phase-contrast imaging; real-time imaging
 Abstract: Velocity-encoded phase-contrast MRI of cardiovascular blood flow commonly relies on electrocardiogram-synchronized cine acquisitions of multiple heartbeats to quantitatively determine the flow of an averaged cardiac cycle. Here, we present a new method for real-time phase-contrast MRI that combines flow-encoding gradients with highly undersampled radial fast low-angle shot acquisitions and phase-sensitive image reconstructions by regularized nonlinear inversion. Apart from calibration studies using steady and pulsatile flow, preliminary in vivo applications focused on through-plane flow in the ascending aorta of healthy subjects. With bipolar velocity-encoding gradients of alternating polarity that overlap the slice-refocusing gradient, the method yields flow-encoded images with an in-plane resolution of 1.8 mm, section thickness of 6 mm and measuring time at 3 T of 24 ms (TR/TE = 3.44/2.76 ms; flip angle, 10º; seven radial spokes per image). Accordingly, phase-contrast maps and corresponding velocity profiles achieve a temporal resolution of 48 ms. The evaluated peak velocities, stroke volumes, flow rates and respective variances over at least 20 consecutive heartbeats are in general agreement with literature data.

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Language(s): eng - English
 Dates: 2011-12-192012-07
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/nbm.1812
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Title: NMR in Biomedicine
Source Genre: Journal
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Pages: - Volume / Issue: 25 (7) Sequence Number: - Start / End Page: 917 - 924 Identifier: ISSN: 0952-3480
CoNE: /journals/resource/954925574973