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  The potential of microvessel density in prediction of infarct growth: A two-month experimental study in vessel size imaging

Xu, C., Schmidt, W. U., Galinovic, I., Villringer, K., Hotter, B., Ostwaldt, A.-C., et al. (2012). The potential of microvessel density in prediction of infarct growth: A two-month experimental study in vessel size imaging. Cerebrovascular Diseases, 33(4), 303-309. doi:10.1159/000335302.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-A3B4-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-5C19-A
Genre: Journal Article

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 Creators:
Xu, Chao1, Author              
Schmidt, Wolf U.H.1, Author
Galinovic, Ivana1, Author
Villringer, Kersten1, Author
Hotter, Benjamin1, Author
Ostwaldt, Ann-Christin1, Author
Denisova, Natalia1, Author
Kellner, Elias1, Author
Kiselev, Valerij1, Author
Fiebach, Jochen B.1, Author
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1External Organizations, ou_persistent22              

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Free keywords: Acute stroke; Magnetic resonance imaging; Brain ischemia; Microvessels; Perfusion imaging
 Abstract: Objectives: Vessel size imaging is a novel technique to evaluate pathological changes of the microvessel density quantity Q and the mean vessel size index (VSI). As a follow-up study, we assessed these parameters for microscopic description of ischemic penumbra and their potentials in predicting lesion growth. Methods: Seventy-five patients with a perfusion-diffusion mismatch were examined within 24 h from symptom onset. We defined three regions of interest: the initial infarct (INF), the ischemic penumbra (IPE), and the healthy region (HEA) symmetric to the IPE. For 23 patients with a 6th-day follow-up, IPE regions were divided into areas of infarct growth and areas of oligemia. Result: The median values of Q and VSI were: for INF 0.29 s-1/3 and 15.8 µm, for IPE 0.33 s-1/3 and 20.6 µm and for HEA 0.36 s-1/3 and 17.4 µm. The Q in the IPE was significantly smaller than in HEA, and VSI was significantly larger. The Q with a threshold of 0.32 s-1/3 predicted the final infarction with a sensitivity of 69% and a specificity of 64%. Conclusions: The reduced Q and increased VSI in the IPE confirmed our previous pilot results. Although Q showed a trend to identify the severity of ischemia in an overall voxel population, its potential in predicting infarct growth needs to be further tested in a larger cohort including a clear status of reperfusion and recanalization.

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Language(s): eng - English
 Dates: 2011-07-112011-11-172012-02-152012-04
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1159/000335302
PMID: 22343905
Other: Epub 2012
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Title: Cerebrovascular Diseases
  Other : Cerebrovasc. Dis.
Source Genre: Journal
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Publ. Info: Basel : Karger
Pages: - Volume / Issue: 33 (4) Sequence Number: - Start / End Page: 303 - 309 Identifier: ISSN: 1015-9770
CoNE: https://pure.mpg.de/cone/journals/resource/954925585262