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  Dynamic hysteresis between gradient echo and spin echo attenuations in dynamic susceptibility contrast imaging

Xu, C., Kiselev, V. G., Möller, H. E., & Fiebach, J. E. (2013). Dynamic hysteresis between gradient echo and spin echo attenuations in dynamic susceptibility contrast imaging. Magnetic Resonance in Medicine, 69(4), 981-991. doi:10.1002/mrm.24326.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-A56E-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-AFD7-6
Genre: Journal Article

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Xu_2012_Dynamic.pdf (Preprint), 628KB
 
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 Creators:
Xu, Chao1, 2, Author              
Kiselev, Valerij G.3, Author
Möller, Harald E.2, Author              
Fiebach, Jochen E.1, Author
Affiliations:
1Academic Neuroradiology, Center for Stroke Research, Charité University Medicine Berlin, Germany, ou_persistent22              
2Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
3Department of Radiology, University Medical Center, Freiburg, Germany, ou_persistent22              

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Free keywords: Dynamic susceptibility contrast; Transverse relaxation rate constant; Hysteresis; Microvasculature; Perfusion
 Abstract: Perfusion measurements using dynamic susceptibility contrast imaging provide additional information about the mean vessel size of microvasculature when supplemented with a dual gradient echo (GE) – spin echo (SE) contrast. Dynamic increase in the corresponding transverse relaxation rate constant changes, ΔR2GE and ΔR2SE, forms a loop on the (ΔRmath image, ΔR2GE) plane, rather than a reversible line. The shape of the loop and the direction of its passage differentiate between healthy brain and pathological tissue, such as tumour and ischemic tissue. By considering a tree model of microvasculature, the direction of the loop is found to be influenced mainly by the relative arterial and venous blood volume, as well as the tracer bolus dispersion. A parameter Λ is proposed to characterize the direction and shape of the loop, which might be considered as a novel imaging marker for describing the pathology of cerebrovascular network.

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Language(s): eng - English
 Dates: 2012-03-092011-12-202012-04-132012-05-182013-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/mrm.24326
PMID: 22611004
Other: Epub 2012
 Degree: -

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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 69 (4) Sequence Number: - Start / End Page: 981 - 991 Identifier: ISSN: 0740-3194
CoNE: /journals/resource/954925538149