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  A high-resolution anatomical atlas of the transcriptome in the mouse embryo.

Diez-Roux, G., Banfi, S., Sultan, M., Geffers, L., Anand, S., Rozado, D., et al. (2011). A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biology, 9(1): e1000582. doi:10.1371/journal.pbio.1000582.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-A607-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-CE88-4
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Creators

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 Creators:
Diez-Roux, G., Author
Banfi, S., Author
Sultan, M., Author
Geffers, L.1, Author              
Anand, S., Author
Rozado, D., Author
Magen, A., Author
Canidio, E., Author
Pagani, M., Author
Peluso, I., Author
Lin-Marq, N., Author
Koch, M., Author
Bilio, M., Author
Cantiello, I., Author
Verde, R., Author
De Masi, C., Author
Bianchi, S. A., Author
Cicchini, J., Author
Perroud, E., Author
Mehmeti, S., Author
Dagand, E., AuthorSchrinner, S., AuthorNürnberger, A., AuthorSchmidt, K., AuthorMetz, K., AuthorZwingmann, C., AuthorBrieske, N., AuthorSpringer, C., AuthorMartinez Hernandez, A.1, Author              Herzog, S.1, Author              Grabbe, F.1, Author              Sieverding, C.1, Author              Fischer, B.1, Author              Schrader, K.1, Author              Brockmeyer, M.1, Author              Dettmer, S., AuthorHelbig, C.2, Author              Alunni, V., AuthorBattaini, M. A., AuthorMura, C., AuthorHenrichsen, C. N., AuthorGarcia-Lopez, R., AuthorEchevvaria, D., AuthorPuelles, E., AuthorGarcia-Galero, E., AuthorKruse, S., AuthorUhr, M.1, Author              Kauck, C.1, Author              Feng, G., AuthorMilyaev, N., AuthorOng, C. K., AuthorKumar, L., AuthorLam, M., AuthorSemple, C. A., AuthorGyenesei, A., AuthorMundlos, S., AuthorRadelof, U., AuthorLehrach, H., AuthorSarmientos, P., AuthorReymond, A., AuthorDavidson, D. R., AuthorDolle, P., AuthorAntonarakis, S. E., AuthorYaspo, M. L., AuthorMartinez, S., AuthorBaldock, R. A., AuthorEichele, G.1, Author              Ballbio, A., Author more..
Affiliations:
1Department of Genes and Behavior, MPI for biophysical chemistry, Max Planck Society, ou_persistent34              
2Research Group of Circadian Rhythms, MPI for biochemical chemistry, Max Planck Society, ou_578594              

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 Abstract: Ascertaining when and where genes are expressed is of crucial importance to understanding or predicting the physiological role of genes and proteins and how they interact to form the complex networks that underlie organ development and function. It is, therefore, crucial to determine on a genome-wide level, the spatio-temporal gene expression profiles at cellular resolution. This information is provided by colorimetric RNA in situ hybridization that can elucidate expression of genes in their native context and does so at cellular resolution. We generated what is to our knowledge the first genome-wide transcriptome atlas by RNA in situ hybridization of an entire mammalian organism, the developing mouse at embryonic day 14.5. This digital transcriptome atlas, the Eurexpress atlas (http://www.eurexpress.org), consists of a searchable database of annotated images that can be interactively viewed. We generated anatomy-based expression profiles for over 18,000 coding genes and over 400 microRNAs. We identified 1,002 tissue-specific genes that are a source of novel tissue-specific markers for 37 different anatomical structures. The quality and the resolution of the data revealed novel molecular domains for several developing structures, such as the telencephalon, a novel organization for the hypothalamus, and insight on the Wnt network involved in renal epithelial differentiation during kidney development. The digital transcriptome atlas is a powerful resource to determine co-expression of genes, to identify cell populations and lineages, and to identify functional associations between genes relevant to development and disease.

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Language(s): eng - English
 Dates: 2011-01-18
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1371/journal.pbio.1000582
 Degree: -

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Title: PLoS Biology
Source Genre: Journal
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Pages: 13 Volume / Issue: 9 (1) Sequence Number: e1000582 Start / End Page: - Identifier: -