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  Cortical thickness in primary sensorimotor cortex influences the effectiveness of paired associative stimulation

Conde, V., Vollmann, H., Sehm, B., Taubert, M., Villringer, A., & Ragert, P. (2012). Cortical thickness in primary sensorimotor cortex influences the effectiveness of paired associative stimulation. NeuroImage, 60(2), 864-870. doi:10.1016/j.neuroimage.2012.01.052.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-A890-F Version Permalink: http://hdl.handle.net/21.11116/0000-0003-B019-A
Genre: Journal Article

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Conde_2012_Cortical.pdf (Publisher version), 600KB
 
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 Creators:
Conde, Virginia1, Author              
Vollmann, Henning1, Author              
Sehm, Bernhard1, Author              
Taubert, Marco1, Author              
Villringer, Arno1, 2, Author              
Ragert, Patrick1, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Mind and Brain Institute, Charité and Humboldt University, Berlin, Germany, ou_persistent22              

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Free keywords: Paired associative stimulation (PAS); Primary motor cortex (M1); Primary somatosensory cortex (S1); Transcranial magnetic stimulation (TMS); Voxel-based cortical thickness (VBCT)
 Abstract: Non-invasive brain stimulation protocols in general and paired associative stimulation (PAS) in particular seem to alter corticospinal excitability and thereby to influence behaviour with a high degree of inter-subject variability. The cause of this variability is multidimensional and to some extent still unknown. Here, we tested the hypothesis that individual variations in cortical thickness can explain some of the variability of PAS-induced excitability changes. Ten minutes of a facilitatory PAS protocol (PASLTP) rapidly increased corticospinal excitability in the majority of the subjects (14/19 subjects) while others showed no such effect (5/19 subjects). A whole brain correlation analysis based on high resolution T1-weighted images revealed a significant positive relationship of PASLTP-induced excitability changes with cortical thickness of the underlying left sensorimotor cortex (SM1) only. Cortical thickness alone, among other potential influencing factors, explained about half of the PASLTP variance, indicating that subjects with a strong after-effect were those with thicker gray matter in this region. Based on these findings, we provide novel evidence that local brain structure influences the individual amount of functional plasticity induced by PASLTP. While the underlying neurophysiological and/or anatomical reasons for this effect still remain elusive at this point, we conclude that cortical thickness should be considered as an important and until now not recognized modulating factor in studies employing non-invasive brain stimulation techniques.

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Language(s): eng - English
 Dates: 2011-12-092011-10-192012-01-052012-01-132012-04-02
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2012.01.052
PMID: 22266412
Other: Epub 2012
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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 60 (2) Sequence Number: - Start / End Page: 864 - 870 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166