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  Sensorimotor Mismatch Signals in Primary Visual Cortex of the Behaving Mouse

Keller, G. B., Bonhoeffer, T., & Hübener, M. (2012). Sensorimotor Mismatch Signals in Primary Visual Cortex of the Behaving Mouse. NEURON, 74(5), 809-815. doi:10.1016/j.neuron.2012.03.040.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-C3B1-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-C3B2-2
Genre: Journal Article

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 Creators:
Keller, Georg B.1, Author              
Bonhoeffer, Tobias1, Author              
Hübener, Mark1, Author              
Affiliations:
1Department: Cellular and Systems Neurobiology / Bonhoeffer, MPI of Neurobiology, Max Planck Society, ou_1113545              

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Free keywords: RAPID EYE-MOVEMENTS; RECEPTIVE-FIELDS; FUNCTIONAL ARCHITECTURE; NEURAL ACTIVITY; NATURAL SCENES; STRIATE CORTEX; NEURONS; MONKEYS; MOTOR; MICE
 Abstract: Studies in anesthetized animals have suggested that activity in early visual cortex is mainly driven by visual input and is well described by a feedforward processing hierarchy. However, evidence from experiments on awake animals has shown that both eye movements and behavioral state can strongly modulate responses of neurons in visual cortex; the functional significance of this modulation, however, remains elusive. Using visual-flow feedback manipulations during locomotion in a virtual reality environment, we found that responses in layer 2/3 of mouse primary visual cortex are strongly driven by locomotion and by mismatch between actual and expected visual feedback. These data suggest that processing in visual cortex may be based on predictive coding strategies that use motor-related and visual input to detect mismatches between predicted and actual visual feedback.

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Language(s): eng - English
 Dates: 2012-06-07
 Publication Status: Published in print
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

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Title: NEURON
Source Genre: Journal
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Publ. Info: 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA : CELL PRESS
Pages: - Volume / Issue: 74 (5) Sequence Number: - Start / End Page: 809 - 815 Identifier: ISSN: 0896-6273