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  Divergent selection on locally adapted major histocompatibility complex immune genes experimentally proven in the field

Eizaguirre, C., Lenz, T. L., Kalbe, M., & Milinski, M. (2012). Divergent selection on locally adapted major histocompatibility complex immune genes experimentally proven in the field. Ecology Letters, 15(7), 723-731. doi:10.1111/j.1461-0248.2012.01791.x.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-D2EF-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-3B0C-F
Genre: Journal Article

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Eizaguirre_et_al-2012-Ecology_Letters.pdf (Publisher version), 526KB
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Eizaguirre_et_al-2012-Ecology_Letters.pdf
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 Creators:
Eizaguirre, Christophe1, Author              
Lenz, Tobias L.1, Author              
Kalbe, Martin2, Author              
Milinski, Manfred1, Author              
Affiliations:
1Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445634              
2Research Group Parasitology, Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445643              

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Free keywords: adaptive radiation; host–parasite coevolution; local adaptation; major histocompatibility complex
 Abstract: Although crucial for the understanding of adaptive evolution, genetically resolved examples of local adaptation are rare. To maximize survival and reproduction in their local environment, hosts should resist their local parasites and pathogens. The major histocompatibility complex (MHC) with its key function in parasite resistance represents an ideal candidate to investigate parasite-mediated local adaptation. Using replicated field mesocosms, stocked with second-generation lab-bred three-spined stickleback hybrids of a lake and a river population, we show local adaptation of MHC genotypes to population-specific parasites, independently of the genetic background. Increased allele divergence of lake MHC genotypes allows lake fish to fight the broad range of lake parasites, whereas more specific river genotypes confer selective advantages against the less diverse river parasites. Hybrids with local MHC genotype gained more body weight and thus higher fitness than those with foreign MHC in either habitat, suggesting the evolutionary significance of locally adapted MHC genotypes.

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Language(s): eng - English
 Dates: 2012-07
 Publication Status: Published in print
 Pages: -
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 Rev. Method: -
 Identifiers: eDoc: 610633
DOI: 10.1111/j.1461-0248.2012.01791.x
Other: 2921/S 39266
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Title: Ecology Letters
Source Genre: Journal
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Pages: - Volume / Issue: 15 (7) Sequence Number: - Start / End Page: 723 - 731 Identifier: ISSN: 1461-023x (print)
ISSN: 1461-0248 (online)