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  Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci

Folseraas, T., Melum, E., Rausch, P., Juran, B. D., Ellinghaus, E., Shiryaev, A., et al. (2012). Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci. Journal of Hepatology, 57(2), 366-375. doi:10.1016/j.jhep.2012.03.031.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-D34E-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-3B00-B
Genre: Journal Article

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 Creators:
Folseraas, Trine, Author
Melum, Espen, Author
Rausch, Philipp1, Author              
Juran, Brian D., Author
Ellinghaus, Eva, Author
Shiryaev, Alexey, Author
Laerdahl, Jon K., Author
Ellinghaus, David, Author
Schramm, Christoph, Author
Weismüller, Tobias J., Author
Gotthardt, Daniel Nils, Author
Hov, Johannes Roksund, Author
Clausen, Ole Petter, Author
Weersma, Rinse K., Author
Janse, Marcel, Author
Boberg, Kirsten Muri, Author
Björnsson, Einar, Author
Marschall, Hanns -Ulrich, Author
Cleynen, Isabelle, Author
Rosenstiel, Philip, Author
Holm, Kristian, AuthorTeufel, Andreas, AuthorRust, Christian, AuthorGieger, Christian, AuthorWichmann, H-Erich, AuthorBergquist, Annika, AuthorRyu, Euijung, AuthorPonsioen, Cyriel Y., AuthorRunz, Heiko, AuthorSterneck, Martina, AuthorVermeire, Severine, AuthorBeuers, Ulrich, AuthorWijmenga, Cisca, AuthorSchrumpf, Erik, AuthorManns, Michael P., AuthorLazaridis, Konstantinos N., AuthorSchreiber, Stefan, AuthorBaines, John F.1, Author              Franke, Andre, AuthorKarlsen, Tom H., Author more..
Affiliations:
1Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445638              

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Free keywords: primary sclerosing cholangitis; genome-wide association study; single nucleotide polymorphism; immunogenetics.
 Abstract: Background & Aims: A limited number of genetic risk factors have been reported in primary sclerosing cholangitis (PSC). To discover further genetic susceptibility factors for PSC, we followed up on a second tier of single nucleotide polymorphisms (SNPs) from a genome-wide association study (GWAS). Methods:We analyzed 45 SNPs in 1221 PSC cases and 3508 controls. The association results from the replication analysis and the original GWAS (715 PSC cases and 2962 controls) were combined in a meta-analysis comprising 1936 PSC cases and 6470 controls. We performed an analysis of bile microbial community composition in 39 PSC patients by 16S rRNA sequencing. Results: Seventeen SNPs representing 12 distinct genetic loci achieved nominal significance (preplication <0.05) in the replication. The most robust novel association was detected at chromosome 1p36 (rs3748816; pcombined = 2.1 10 8) where the MMEL1 and TNFRSF14 genes represent potential disease genes. Eight additional novel loci showed suggestive evidence of association (prepl <0.05). FUT2 at chromosome 19q13 (rs602662; pcomb = 1.9 10 6, rs281377; pcomb = 2.1 10 6 and rs601338; pcomb = 2.7 10 6) is notable due to its implication in altered susceptibility to infectious agents. We found that FUT2 secretor status and genotype defined by rs601338 significantly influence biliary microbial community composition in PSC patients. Conclusions:We identify multiple new PSC risk loci by extended analysis of a PSC GWAS. FUT2 genotype needs to be taken into account when assessing the influence of microbiota on biliary pathology in PSC.

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Language(s): eng - English
 Dates: 2012-08
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 610654
DOI: 10.1016/j.jhep.2012.03.031
Other: 2926/S 39271
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Title: Journal of Hepatology
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 57 (2) Sequence Number: - Start / End Page: 366 - 375 Identifier: ISSN: 0168-8278 (print)
ISSN: 1600-0641 (online)