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  The genetic structure and history of Africans and African Americans

Tishkoff, S. A., Reed, F. A., Friedlaender, F. R., Ehret, C., Ranciaro, A., Froment, A., et al. (2009). The genetic structure and history of Africans and African Americans. Science, 324(5930), 1035-1044. doi:10.1126/science.1172257.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-D5B7-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-D5B8-B
Genre: Journal Article

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Tishkoff_2009.pdf (Publisher version), 7MB
 
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 Creators:
Tishkoff, Sarah A., Author
Reed, Floyd A.1, Author              
Friedlaender, Françoise R., Author
Ehret, Christopher, Author
Ranciaro, Alessia, Author
Froment, Alain, Author
Hirbo, Jibril B., Author
Awomoyi, Agnes A., Author
Bodo, Jean-Marie, Author
Doumbo, Ogobara, Author
Ibrahim, Muntaser, Author
Juma, Abdalla T., Author
Kotze, Maritha J., Author
Lema, Godfrey, Author
Moore, Jason H., Author
Mortensen, Holly, Author
Nyambo, Thomas B., Author
Omar, Sabah A., Author
Powell, Kweli, Author
Pretorius, Gideon S., Author
Smith, Michael W., AuthorThera, Mahamadou A., AuthorWambebe, Charles, AuthorWeber, James L., AuthorWilliams, Scott M., Author more..
Affiliations:
1Research Group Population Genetics, Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445646              

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 Abstract: Africa is the source of all modern humans, but characterization of genetic variation and of relationships among populations across the continent has been enigmatic. We studied 121 African populations, four African American populations, and 60 non-African populations for patterns of variation at 1327 nuclear microsatellite and insertion/deletion markers. We identified 14 ancestral population clusters in Africa that correlate with self-described ethnicity and shared cultural and/or linguistic properties. We observed high levels of mixed ancestry in most populations, reflecting historical migration events across the continent. Our data also provide evidence for shared ancestry among geographically diverse hunter-gatherer populations (Khoesan speakers and Pygmies). The ancestry of African Americans is predominantly from Niger-Kordofanian (similar to 71%), European (similar to 13%), and other African (similar to 8%) populations, although admixture levels varied considerably among individuals. This study helps tease apart the complex evolutionary history of Africans and African Americans, aiding both anthropological and genetic epidemiologic studies.

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Language(s): eng - English
 Dates: 2009-05-22
 Publication Status: Published in print
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 Identifiers: eDoc: 452090
DOI: 10.1126/science.1172257
Other: 2741/S 39064
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Title: Science
Source Genre: Journal
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Pages: - Volume / Issue: 324 (5930) Sequence Number: - Start / End Page: 1035 - 1044 Identifier: ISSN: 0036-8075 (print)
ISSN: 1095-9203 (online)