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  An ancient evolutionary origin of genes associated with human genetic diseases

Domazet-Lošo, T., & Tautz, D. (2008). An ancient evolutionary origin of genes associated with human genetic diseases. Molecular Biology and Evolution, 25(12), 2699-2707. doi:10.1093/molbev/msn214.

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Domazet-Lošo, Tomislav1, Author           
Tautz, Diethard1, Author           
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1Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              

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 Abstract: Several thousand genes in the human genome have been linked to a heritable genetic disease. The majority of these appear to be nonessential genes (i.e., are not embryonically lethal when inactivated), and one could therefore speculate that they are late additions in the evolutionary lineage toward humans. Contrary to this expectation, we find that they are in fact significantly overrepresented among the genes that have emerged during the early evolution of the metazoa. Using a phylostratigraphic approach, we have studied the evolutionary emergence of such genes at 19 phylogenetic levels. The majority of disease genes was already present in the eukaryotic ancestor, and the second largest number has arisen around the time of evolution of multicellularity. Conversely, genes specific to the mammalian lineage are highly underrepresented. Hence, genes involved in genetic diseases are not simply a random subset of all genes in the genome but are biased toward ancient genes.

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Language(s): eng - English
 Dates: 2008-12
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 397368
DOI: 10.1093/molbev/msn214
Other: 2656/S 38937
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Title: Molecular Biology and Evolution
  Alternative Title : Mol. Biol. Evol.
Source Genre: Journal
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Pages: - Volume / Issue: 25 (12) Sequence Number: - Start / End Page: 2699 - 2707 Identifier: ISSN: 0737-4038 (print)
ISSN: 1537-1719 (online)