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  Biased distributions and decay of long interspersed nuclear elements in the chicken genome

Abrusán, G., Krambeck, H.-J., Junier, T., Giordano, J., & Warburton, P. E. (2008). Biased distributions and decay of long interspersed nuclear elements in the chicken genome. Genetics, 178(1), 573-581. doi:10.1534/genetics.106.061861.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-D6F4-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-D6F5-8
Genre: Journal Article

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Abrusán, György1, Author              
Krambeck, Hans-Jürgen1, Author              
Junier, Thomas, Author
Giordano, Joti, Author
Warburton, Peter E., Author
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1Department Ecophysiology, Max Planck Institute for Limnology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_976547              

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 Abstract: The genomes of birds are much smaller than mammalian genomes, and transposable elements (TEs) make up only 10% of the chicken genome, compared with the 45% of the human genome. To study the mechanisms that constrain the copy numbers of TEs, and as a consequence the genome size of birds, we analyzed the distributions of LINEs (CRI's) and SINEs (MIRs) on the chicken autosomes and Z chromosome. We show that (1) CRI repeats are longest on the Z chromosome and their length is negatively correlated with the local GC content; (2) the decay of CRI elements is highly biased, and the 5'-ends of the insertions are lost much faster than their 3'-ends; (3) the GC distribution of CRI repeats shows a bimodal pattern with repeats enriched in both AT-rich and GC-rich regions of the genome, but the CRI families show large differences in their GC distribution; and (4) the few MIRs in the chicken are most abundant in regions with intermediate GC content. Our results indicate that the primary mechanism that removes repeats front the chicken genome is ectopic exchange and that the low abundance of repeats in avian genomes is likely to be the consequence of their high recombination rates.

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Language(s): eng - English
 Dates: 2008-01
 Publication Status: Published in print
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 Identifiers: eDoc: 354868
DOI: 10.1534/genetics.106.061861
Other: 2601/S 38764
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Title: Genetics
Source Genre: Journal
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Pages: - Volume / Issue: 178 (1) Sequence Number: - Start / End Page: 573 - 581 Identifier: ISSN: 0016-6731