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  Cyclic neutropenia in mammals

Pacheco, J. M., Traulsen, A., Antal, T., & Dingli, D. (2008). Cyclic neutropenia in mammals. American Journal of Hematology, 83(12), 920-921. doi:10.1002/ajh.21295.

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Pacheco, Jorge M., Author
Traulsen, Arne1, 2, Author           
Antal, Tibor, Author
Dingli, David, Author
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1Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445634              
2Research Group Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445641              

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 Abstract: Cyclic neutropenia (CN) has been well documented in humans and the gray collie. A recent model of the architecture and dynamics of hematopoiesis has been used to provide insights into the mechanism of cycling of this disorder. It provides a link between the cycling period and the cells where the mutated ELA2 is expressed. Assuming that the biologic defect in CN is the same in dogs, and the observation that the structure of hematopoiesis is invariant across mammals, we use allometric scaling techniques to correctly predict the period of cycling in the gray collie and extend it to other mammals from mice to elephants. This work provides additional support for the relevance of animal models to understand disease but cautions that disease dynamics in model animals are different and this has to be taken into consideration when planning experiments

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Language(s): eng - English
 Dates: 2008
 Publication Status: Issued
 Pages: -
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 Rev. Type: -
 Identifiers: eDoc: 395907
DOI: 10.1002/ajh.21295
Other: 2644/S 38930
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Title: American Journal of Hematology
  Alternative Title : Am. J. Hematol.
Source Genre: Journal
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Pages: - Volume / Issue: 83 (12) Sequence Number: - Start / End Page: 920 - 921 Identifier: ISSN: 0361-8609 (print)
ISSN: 1096-8652 (onine)