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  Innate versus adaptive immunity in sticklebacks: evidence for trade-offs from a selection experiment

Wegner, K. M., Kalbe, M., & Reusch, T. B. H. (2007). Innate versus adaptive immunity in sticklebacks: evidence for trade-offs from a selection experiment. Evolutionary Ecology, 21(4), 473-483. doi:10.1007/s10682-006-9129-5.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-D776-F Version Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-D777-D
Genre: Journal Article

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wegner_2007.pdf (Publisher version), 186KB
 
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 Creators:
Wegner, K. Mathias1, Author              
Kalbe, Martin1, 2, Author              
Reusch, Thorsten B. H.1, 3, Author              
Affiliations:
1Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445634              
2Research Group Parasitology, Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445643              
3Department Ecophysiology, Max Planck Institute for Limnology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_976547              

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Free keywords: Major histocompatibility complex (MHC); Ecological immunity; Innate resistance; Adaptive immunity; Gene expression; Three-spined stickleback (Gasterosteus aculeatus); Parasites; Artificial selection
 Abstract: In vertebrates, the immune system consists of two arms of different characteristics: the innate and the acquired immune response. Parasites that are only shortly exposed to the immune system are most efficiently attacked by fast, constitutive innate immune mechanisms. Here, we experimentally selected within four fish families for high innate resistance versus susceptibility of three-spined sticklebacks (Gasterosteus aculeatus) against infection with the eye-fluke (Diplostomum pseudospathacaeum), a parasite whose metacercariae are protected from the immune system within the eye lens. We predicted that in families with high susceptibility, the adaptive immune system would be upregulated when challenged with infection. In accordance, we found that MHC class IIB expression is increased by approximately 50% in those lines selected for higher parasite load (i.e. low innate response). This suggests extensive genetic correlations between innate and adaptive immune system and/or crosstalk between both lines of defense. An efficient, specific innate immune response might reduce overall activation of the immune system and potentially alleviate associated effects of immunopathology.

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Language(s): eng - English
 Dates: 2007-07
 Publication Status: Published in print
 Pages: -
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 Rev. Method: -
 Identifiers: eDoc: 307654
DOI: 10.1007/s10682-006-9129-5
Other: 2562/S 38712
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Title: Evolutionary Ecology
  Alternative Title : Evol Ecol
Source Genre: Journal
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Pages: - Volume / Issue: 21 (4) Sequence Number: - Start / End Page: 473 - 483 Identifier: ISSN: 0269-7653 (Print)
ISSN: 1573-8477 (Online)