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  Polymorphism and signature of selection in the MHC class I genes of the three-spined stickleback Gasterosteus aculeatus

Schaschl, H., & Wegner, K. M. (2006). Polymorphism and signature of selection in the MHC class I genes of the three-spined stickleback Gasterosteus aculeatus. Journal of Fish Biology, 89(Suppl. B), 177-188. doi:10.1111/j.1095-8649.2006.01223.x.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-D825-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-D826-C
Genre: Journal Article

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schaschl_2006.pdf (Publisher version), 151KB
 
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 Creators:
Schaschl, H.1, Author              
Wegner, K. M.1, Author              
Affiliations:
1Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445634              

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Free keywords: Gasterosteus aculeatus; MHC class I diversity; positive selection; SSCP
 Abstract: The role and intensity of positive selection maintaining the polymorphism of major histocompatibility complex (MHC) class I genes in the three-spined stickleback Gasterosteus aculeams was investigated. The highly polymorphic set of MHC class I genes found was organized in a single linkage group. Between 5 and 14 sequence variants per individual were identified by single-stranded conformation polymorphism (SSCP) analysis. Segregation analysis studied in 10 three-spined stickleback families followed the expected pattern of Mendelian inheritance. The gamete fusion in three-spined stickleback thus seems to be random with respect to the MHC class I genes. The DNA sequence analyses showed that the expressed MHC class I loci are under strong selection pressure, possibly mediated by parasites. Codons that were revealed to be under positive selection are potentially important in antigen binding. MHC class I sequences did not form significant supported clusters within a phylogenetic tree. Analogous to MHC class II genes, it was not possible to assign the class I sequences to a specific locus, suggesting that the class I genes may have been generated by recent gene duplication.

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Language(s): eng - English
 Dates: 2006-12
 Publication Status: Published in print
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 Identifiers: eDoc: 299088
DOI: 10.1111/j.1095-8649.2006.01223.x
Other: 2525/S 38666
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Title: Journal of Fish Biology
Source Genre: Journal
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Pages: - Volume / Issue: 89 (Suppl. B) Sequence Number: - Start / End Page: 177 - 188 Identifier: ISSN: 0022-1112