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  MHC genes and oxidative stress in sticklebacks: an immuno-ecological approach

Kurtz, J., Wegner, K. M., Kalbe, M., Reusch, T. B. H., Schaschl, H., Hasselquist, D., et al. (2006). MHC genes and oxidative stress in sticklebacks: an immuno-ecological approach. Proceedings of the Royal Society B-Biological Sciences, 273(1592), 1407-1414. doi:10.1098/rspb.2005.3450.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-D8B0-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-D8B1-0
Genre: Journal Article

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 Creators:
Kurtz, Joachim1, Author              
Wegner, K. Mathias1, Author              
Kalbe, Martin1, 2, Author              
Reusch, Thorsten B. H.1, 3, Author              
Schaschl, Helmut1, Author              
Hasselquist, Dennis, Author
Milinski, Manfred1, Author              
Affiliations:
1Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445634              
2Research Group Parasitology, Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445643              
3Department Ecophysiology, Max Planck Institute for Limnology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_976547              

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Free keywords: major histocompatability complex; immunocompetence; oxidative stress; parasite resistance; coevolution; three-spined stickleback
 Abstract: Individual variation in the susceptibility to infection may result from the varying ability of hosts to specifically recognize different parasite strains. Alternatively, there could be individual host differences in fitness costs of immune defence. Although, these two explanations are not mutually exclusive, they have so far been treated in separate experimental approaches. To analyse potential relationships, we studied body condition and oxidative stress, which may reflect costs of immunity, in three-spined sticklebacks that had been experimentally exposed to three species of naturally occurring parasite. These sticklebacks differed in a trait, which is crucial to specific parasite defence, i.e. individual genetic diversity at major histocompatibility complex (MHC) class IIB loci. Oxidative stress was quantified as tissue acrolein, a technique that has been applied to questions of immuno-ecology for the first time. We measured gene expression at the MHC and other estimates of immune activation. We found that fish with high levels of MHC expression had poor condition and elevated oxidative stress. These results indicate that MHC-based specific immunity is connected with oxidative stress. They could, thus, also be relevant in the broader context of the evolution of sexually selected signals that are based on carotenoids and are, thus supposed to reflect oxidative stress resistance.

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Language(s): eng - English
 Dates: 2006-06-07
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 281051
DOI: 10.1098/rspb.2005.3450
Other: 2443/S 38489
 Degree: -

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Title: Proceedings of the Royal Society B-Biological Sciences
  Alternative Title : Proc. R. Soc. B
Source Genre: Journal
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Pages: - Volume / Issue: 273 (1592) Sequence Number: - Start / End Page: 1407 - 1414 Identifier: ISSN: 0962-8452