English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Recombination and the origin of sequence diversity in the DRB MHC class II locus in chamois (Rupicapra spp.)

Schaschl, H., Suchentrunk, F., Hammer, S., & Goodman, S. J. (2005). Recombination and the origin of sequence diversity in the DRB MHC class II locus in chamois (Rupicapra spp.). Immunogenetics, 57(1-2), 108-115. doi:10.1007/s00251-005-0784-4.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-D9D4-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-D9D5-7
Genre: Journal Article

Files

show Files
hide Files
:
schaschl_2005.pdf (Publisher version), 147KB
 
File Permalink:
-
Name:
schaschl_2005.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Evolutionary Biology, Plön; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Schaschl, Helmut1, Author              
Suchentrunk, Franz, Author
Hammer, Sabine, Author
Goodman, Simon J., Author
Affiliations:
1Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445634              

Content

show
hide
Free keywords: MHC class II diversity; chamois; recombination; allelic polymorphism
 Abstract: We examined the evolutionary processes contributing to genetic diversity at the major histocompatibility complex (MHC) class II DRB locus in chamois (Rupicapra spp., subfamily Caprinae). We characterised the pattern of intragenic recombination ( or homologous gene conversion) and quantified the amount of recombination in the geneaogical history of the two chamois species, Pyrenean chamois ( Rupicapra pyrenaica) and Alpine chamois ( Rupicapra rupicapra). We found evidence for intragenic recombination, and the estimated amount of population recombination suggests that recombination has been a significant process in generating DRB allelic diversity in the genealogical history of the genus Rupicapra. Moreover, positive selection appears to act on the same peptide-binding residues in both analysed chamois species, but not in identical intensity. Recombination coupled with positive selection drives the rapid evolution at the peptide-binding sites in the MHC class II DRB gene. Many chamois MHC class II DRB alleles are thus much younger than previously assumed.

Details

show
hide
Language(s): eng - English
 Dates: 2005-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 228902
DOI: 10.1007/s00251-005-0784-4
Other: 2387/S 38370
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Immunogenetics
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 57 (1-2) Sequence Number: - Start / End Page: 108 - 115 Identifier: ISSN: 0093-7711