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  Rapid evolution of the MH class I locus results in different allelic compositions in recently diverged populations of Atlantic salmon

Consuegra, S., Megens, H.-J., Schaschl, H., Leon, K., Stet, R. J. M., & Jordan, W. C. (2005). Rapid evolution of the MH class I locus results in different allelic compositions in recently diverged populations of Atlantic salmon. Molecular Biology and Evolution, 22(4), 1095-1106. doi:10.1093/molbev/msi096.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-D9DC-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-D9DD-8
Genre: Journal Article

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 Creators:
Consuegra, S., Author
Megens, H.-J., Author
Schaschl, H.1, Author              
Leon, K., Author
Stet, R. J. M., Author
Jordan, W. C., Author
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1Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445634              

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Free keywords: MHC; recombination; positive selection; Atlantic salmon; Salmo salar
 Abstract: We compared major histocompatibility class I allelic diversity in two currently reproductively isolated Atlantic salmon (Salmo salar) populations (Irish and Norwegian) with a common postglacial origin in order to test for among-population differences in allelic composition and patterns of recombination and point mutation. We also examined the evidence for adaptive molecular divergence at this locus by analyzing the rate of amino acid replacement in relation to a neutral expectation. Contrary to our prediction, and in contrast to the situation for other genetic markers, the two populations have almost nonoverlapping sets of major histocompatibility class I alleles. Although there is a strong signal of point mutation that predates population divergence, recent recombination, acting in similar, but not identical, ways in both populations appears to be a significant force in creating new alleles. Moreover, selection acting on peptide-binding residues seems to favor new recombinant alleles and is likely to be responsible for the rapid divergence between populations.

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Language(s): eng - English
 Dates: 2005-04
 Publication Status: Published in print
 Pages: -
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 Rev. Method: -
 Identifiers: eDoc: 233932
DOI: 10.1093/molbev/msi096
Other: 2369/S 38393
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Title: Molecular Biology and Evolution
  Alternative Title : Mol. Biol. Evol.
Source Genre: Journal
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Pages: - Volume / Issue: 22 (4) Sequence Number: - Start / End Page: 1095 - 1106 Identifier: ISSN: 0737-4038