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  Parasites and individual major histocompatibility complex diversity—an optimal choice?

Wegner, K. M., Kalbe, M., Schaschl, H., & Reusch, T. B. H. (2004). Parasites and individual major histocompatibility complex diversity—an optimal choice? Microbes and Infection, 6(12), 1110-1116. doi:doi:10.1016/j.micinf.2004.05.025.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-DA7E-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-DA7F-3
Genre: Journal Article

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wegner_2004.pdf (Publisher version), 174KB
 
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 Creators:
Wegner, K. Mathias1, Author              
Kalbe, Martin1, 2, Author              
Schaschl, Helmut1, Author              
Reusch, Thorsten B. H.1, 3, Author              
Affiliations:
1Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445634              
2Research Group Parasitology, Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445643              
3Department Ecophysiology, Max Planck Institute for Limnology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_976547              

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Free keywords: major histocompatibility complex (MHC); parasites; host-parasite coevolution; balancing selection; heterozygote advantage; mate choice
 Abstract: Overdominant selection or heterozygote advantage can partly explain the extraordinary polymorphism found at classical major histocompatibility complex (MHC) loci. However, several studies employing only single infectious agents often failed to detect it. Here, we review recent studies suggesting that due to the dominant nature of MHC-mediated resistance, a heterozygote advantage is most likely to be detected in multiple pathogen challenges.

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Language(s): eng - English
 Dates: 2004-10
 Publication Status: Published in print
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 Identifiers: eDoc: 233597
DOI: doi:10.1016/j.micinf.2004.05.025
Other: 2365/S 38387
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Title: Microbes and Infection
Source Genre: Journal
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Pages: - Volume / Issue: 6 (12) Sequence Number: - Start / End Page: 1110 - 1116 Identifier: ISSN: 1286-4579