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  Sequence analysis of the MHC class II DRB alleles in Alpine chamois (Rupicapra r. rupicapra)

Schaschl, H., Goodman, S. J., & Suchentrunk, F. (2004). Sequence analysis of the MHC class II DRB alleles in Alpine chamois (Rupicapra r. rupicapra). Developmental and Comparative Immunology, 28(3), 265-277. doi:10.1016/j.dci.2003.08.003.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-DB14-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-DB15-9
Genre: Journal Article

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schaschl_2004.pdf (Publisher version), 261KB
 
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 Creators:
Schaschl, Helmut1, Author              
Goodman, Simon J., Author
Suchentrunk, Franz, Author
Affiliations:
1Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445634              

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Free keywords: MHC; class II beta chain; allelic polymorphism; chamois; caprinae
 Abstract: This study characterises the expressed MHC class 11 DRB gene and its genetic variation in exon 2 among 59 Alpine chamois (Rupicapra r. rupicapra) from several locations in the Eastern Alps plus one population in the Western Alps. The expressed DRB gene contains all the expected characteristics including all of the conserved residues found in other mammalian species. The isolated expressed DRB gene from chamois can be considered orthologous to MHC class 11 DRB genes in other mammalian species. Cattle primers yielded exon 2 sequences of 284 bp length. Sequence analysis revealed 19 DRB exon 2 alleles among 59 chamois. Alleles exhibited a high degree of nucleotide and amino acid polymorphism, with most amino acid variations occurring at positions forming the peptide-binding sites. A significantly higher rate of non-synonymous (dN = 0.053 ± 0.0132) than synonymous (dS = 0.007 ± 0.003) substitutions indicated positive selection for diversity in the DRB locus.

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Language(s): eng - English
 Dates: 2004-03
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 176039
DOI: 10.1016/j.dci.2003.08.003
Other: 2300/S 38175
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Title: Developmental and Comparative Immunology
Source Genre: Journal
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Pages: - Volume / Issue: 28 (3) Sequence Number: - Start / End Page: 265 - 277 Identifier: ISSN: 0145-305X