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  Major histocompatibility complex diversity influences parasite resistance and innate immunity in sticklebacks

Kurtz, J., Kalbe, M., Aeschlimann, P. B., Häberli, M. A., Wegner, K. M., Reusch, T. B. H., et al. (2004). Major histocompatibility complex diversity influences parasite resistance and innate immunity in sticklebacks. Proceedings of the Royal Society of London Series B-Biological Sciences, 271(1535), 197-204. doi:10.1098/rspb.2003.2567.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-DB28-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-DB29-C
Genre: Journal Article

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 Creators:
Kurtz, Joachim1, Author              
Kalbe, Martin1, 2, Author              
Aeschlimann, Peter B.1, Author              
Häberli, Michael A.1, Author              
Wegner, K. Mathias1, Author              
Reusch, Thorsten B. H.1, 3, Author              
Milinski, Manfred1, Author              
Affiliations:
1Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445634              
2Research Group Parasitology, Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445643              
3Department Ecophysiology, Max Planck Institute for Limnology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_976547              

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Free keywords: major histocompatibility complex; immunocompetence; host-parasite coevolution; genetic diversity; mate choice; sexual selection
 Abstract: Proteins of the major histocompatibility complex (MHC) play a central role in the presentation of antigens to the adaptive immune system. The MHC also influences the odour-based choice of mates in humans and several animal taxa. It has recently been shown that female three-spined sticklebacks (Gasterosteus aculeatus) aim at a moderately high MHC diversity in their offspring when choosing a mate. Do they optimize the immune systems of their offspring? Using three-spined sticklebacks that varied in their individual numbers of MHC class IIB molecules, we tested, experimentally, whether allelic diversity at the MHC influences parasite resistance and immune parameters. We found that sticklebacks with low MHC diversity suffered more from parasite infection after experimental exposure to Schistocephalus solidus tapeworms and Glugea anomala microsporidians. They also showed the highest proportion of granulocytes and the strongest respiratory burst reaction, which are correlates of innate immunity. This indicates a strong activity of the innate immune system after challenge by parasites when MHC diversity is suboptimal. Individuals with very high allelic diversity at the MHC seemed inferior to those with moderately high diversity. Such a pattern is consistent with theoretical expectations of an optimal balance between the number of recognizable antigens and self-tolerance

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Language(s): eng - English
 Dates: 2004-01-22
 Publication Status: Published in print
 Pages: -
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 Rev. Method: Peer
 Identifiers: eDoc: 65121
DOI: 10.1098/rspb.2003.2567
Other: 2256/S 38114
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Title: Proceedings of the Royal Society of London Series B-Biological Sciences
  Alternative Title : Proc. R. Soc. Lond. B
Source Genre: Journal
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Pages: - Volume / Issue: 271 (1535) Sequence Number: - Start / End Page: 197 - 204 Identifier: ISSN: 0962-8452