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  G protein regulator 1 (GPR-1) localizes to cortical sites of artificial mechanical indentation in Caenorhabditis elegans zygotes.

Bringmann, H. (2012). G protein regulator 1 (GPR-1) localizes to cortical sites of artificial mechanical indentation in Caenorhabditis elegans zygotes. Cytoskeleton, 69(10), 819-825. doi:10.1002/cm.21066.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-EA45-F Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-2E28-C
Genre: Journal Article

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 Creators:
Bringmann, H.1, Author              
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1Research Group of Sleep and Waking, MPI for biophysical chemistry, Max Planck Society, ou_578607              

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Free keywords: Cytokinesis, mechanosensation, GPR-1/2, C. elegans
 Abstract: Cytokinesis and spindle positioning require the cortical force regulator G Protein Regulator 1/2 (GPR-1/2). GPR-1/2 is thought to localize to sites of cortical force generation. Does GPR-1/2 also act as a sensor for mechanical stimulation? I mechanically stimulated the cortex by indenting it with a glass needle and observed the cortical localization of a YFP::GPR-1 transgene. I found that cortical YFP::GPR-1 accumulated at the site of mechanical indentation. This phenomenon occurred on most of the cortical areas except the site of prospective cytokinesis furrow formation. This result suggests that GPR-1/2 can sense mechanical properties of the cortex, which may be important for GPR-1/2 function regulating spindle positioning and cytokinesis.

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Language(s): eng - English
 Dates: 20122012-10
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1002/cm.21066
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Title: Cytoskeleton
Source Genre: Journal
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Pages: - Volume / Issue: 69 (10) Sequence Number: - Start / End Page: 819 - 825 Identifier: -