English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Genome-wide patterns of standing genetic variation in a marine population of three-spined sticklebacks

Feulner, P. G. D., Chain, F. J. J., Panchal, M., Eizaguirre, C., Kalbe, M., Lenz, T. L., et al. (2013). Genome-wide patterns of standing genetic variation in a marine population of three-spined sticklebacks. Molecular Ecology, 22(3), 635-649. doi:10.1111/j.1365-294X.2012.05680.x.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-EA78-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-3AB2-3
Genre: Journal Article

Files

show Files
hide Files
:
Feulner_2012.pdf (Publisher version), 432KB
Name:
Feulner_2012.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Feulner, Philine G. D., Author
Chain, Frédéric J. J.1, Author              
Panchal, Mahesh1, Author              
Eizaguirre, Christophe1, Author              
Kalbe, Martin2, Author              
Lenz, Tobias L.1, Author              
Mundry, Marvin, Author
Samonte, Irene E.1, Author              
Stoll, Monika, Author
Milinski, Manfred1, Author              
Reusch, Thorsten B. H.1, Author              
Bornberg-Bauer, Erich, Author
Affiliations:
1Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445634              
2Research Group Parasitology, Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445643              

Content

show
hide
Free keywords: copy-number variation; Gasterosteus aculeatus; inversions; population genome evolution; standing genetic variation; structural variation
 Abstract: Since the end of the Pleistocene, the three-spined stickleback (Gasterosteus aculeatus) has repeatedly colonized and adapted to various freshwater habitats probably originating from ancestral marine populations. Standing genetic variation and the underlying genomic architecture both have been speculated to contribute to recent adaptive radiations of sticklebacks. Here, we expand on the current genomic resources of this fish by providing extensive genome-wide variation data from six individuals from a marine (North Sea) stickleback population. Using next-generation sequencing and a combination of pairedend and mate-pair libraries, we detected a wide size range of genetic variation. Among the six individuals, we found more than 7% of the genome is polymorphic, consisting of 2 599 111 SNPs, 233 464 indels and structural variation (SV) (>50 bp) such as 1054 copynumber variable regions (deletions and duplications) and 48 inversions. Many of these polymorphisms affect gene and coding sequences. Based on SNP diversity, we determined outlier regions concordant with signatures expected under adaptive evolution. As some of these outliers overlap with pronounced regions of copy-number variation, we propose the consideration of such SV when analysing SNP data from re-sequencing approaches. We further discuss the value of this resource on genome-wide variation for further investigation upon the relative contribution of standing variation on the parallel evolution of sticklebacks and the importance of the genomic architecture in adaptive radiation.

Details

show
hide
Language(s): eng - English
 Dates: 2012-05-042012-03-072012-05-152012-07-032013-02
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1111/j.1365-294X.2012.05680.x
Other: 2938/S 39283
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Molecular Ecology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Oxford : Blackwell Science
Pages: 15 S. Volume / Issue: 22 (3) Sequence Number: - Start / End Page: 635 - 649 Identifier: ISSN: 0962-1083
ISSN: 1365-294X (online)
CoNE: /journals/resource/954925580119