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  Investigating structural brain changes of dehydration using voxel-based morphometry

Streitbürger, D. P., Möller, H. E., Tittgemeyer, M., Hund-Georgiadis, M., Schroeter, M. L., & Mueller, K. (2012). Investigating structural brain changes of dehydration using voxel-based morphometry. PLoS One, 7(8): e44195. doi:10.1371/journal.pone.0044195.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-EAD6-B Version Permalink: http://hdl.handle.net/21.11116/0000-0003-CDAA-7
Genre: Journal Article

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Streitbuerger_2012_Investigating.pdf (Publisher version), 673KB
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 Creators:
Streitbürger, Daniel Paolo1, Author              
Möller, Harald E.1, Author              
Tittgemeyer, Marc2, Author
Hund-Georgiadis, Margret3, Author
Schroeter, Matthias L.3, 4, Author              
Mueller, Karsten1, Author              
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Max Planck Institute for Neurological Research, Cologne, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

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 Abstract: Dehydration can affect the volume of brain structures, which might imply a confound in volumetric and morphometric studies of normal or diseased brain. Six young, healthy volunteers were repeatedly investigated using three-dimensional T1-weighted magnetic resonance imaging during states of normal hydration, hyperhydration, and dehydration to assess volume changes in gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF). The datasets were analyzed using voxel-based morphometry (VBM), a widely used voxel-wise statistical analysis tool, FreeSurfer, a fully automated volumetric segmentation measure, and SIENAr a longitudinal brain-change detection algorithm. A significant decrease of GM and WM volume associated with dehydration was found in various brain regions, most prominently, in temporal and sub-gyral parietal areas, in the left inferior orbito-frontal region, and in the extra-nuclear region. Moreover, we found consistent increases in CSF, that is, an expansion of the ventricular system affecting both lateral ventricles, the third, and the fourth ventricle. Similar degrees of shrinkage in WM volume and increase of the ventricular system have been reported in studies of mild cognitive impairment or Alzheime s disease during disease progression. Based on these findings, a potential confound in GM and WM or ventricular volume studies due to the subjects’ hydration state cannot be excluded and should be appropriately addressed in morphometric studies of the brain.

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Language(s): eng - English
 Dates: 2012-03-272012-07-302012-08-29
 Publication Status: Published online
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 Rev. Method: Peer
 Identifiers: PMID: 22952926
DOI: 10.1371/journal.pone.0044195
PMC: PMC3430653
Other: Epub 2012
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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 7 (8) Sequence Number: e44195 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: /journals/resource/1000000000277850