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  Levels of integration in cognitive control and sequence processing in the prefrontal cortex

Bahlmann, J., Korb, F. M., Gratton, C., & Friederici, A. D. (2012). Levels of integration in cognitive control and sequence processing in the prefrontal cortex. PLoS One, 7(8): e43774. doi:10.1371/journal.pone.0043774.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-EB5A-C Version Permalink: http://hdl.handle.net/21.11116/0000-0003-CC3B-6
Genre: Journal Article

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 Creators:
Bahlmann, Jörg1, Author              
Korb, Franziska Maria2, Author              
Gratton, Caterina1, Author
Friederici, Angela D.3, Author              
Affiliations:
1Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA, ou_persistent22              
2Center for Cognitive Neuroscience, Duke University, Durham, NC, USA, ou_persistent22              
3Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634551              

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 Abstract: Cognitive control is necessary to flexibly act in changing environments. Sequence processing is needed in language comprehension to build the syntactic structure in sentences. Functional imaging studies suggest that sequence processing engages the left ventrolateral prefrontal cortex (PFC). In contrast, cognitive control processes additionally recruit bilateral rostral lateral PFC regions. The present study aimed to investigate these two types of processes in one experimental paradigm. Sequence processing was manipulated using two different sequencing rules varying in complexity. Cognitive control was varied with different cue-sets that determined the choice of a sequencing rule. Univariate analyses revealed distinct PFC regions for the two types of processing (i.e. sequence processing: left ventrolateral PFC and cognitive control processing: bilateral dorsolateral and rostral PFC). Moreover, in a common brain network (including left lateral PFC and intraparietal sulcus) no interaction between sequence and cognitive control processing was observed. In contrast, a multivariate pattern analysis revealed an interaction of sequence and cognitive control processing, such that voxels in left lateral PFC and parietal cortex showed different tuning functions for tasks involving different sequencing and cognitive control demands. These results suggest that the difference between the process of rule selection (i.e. cognitive control) and the process of rule-based sequencing (i.e. sequence processing) find their neuronal underpinnings in distinct activation patterns in lateral PFC. Moreover, the combination of rule selection and rule sequencing can shape the response of neurons in lateral PFC and parietal cortex.

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Language(s): eng - English
 Dates: 2012-04-162012-07-262012-08-29
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1371/journal.pone.0043774
PMID: 22952762
PMC: PMC3430694
Other: Epub 2012
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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 7 (8) Sequence Number: e43774 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: /journals/resource/1000000000277850