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  Long-term balancing selection at the blood group-related gene B4galnt2 in the genus Mus (Rodentia; Muridae)

Linnenbrink, M., Johnsen, J. M., Montero, I., Brzezinski, C. R., Harr, B., & Baines, J. F. (2011). Long-term balancing selection at the blood group-related gene B4galnt2 in the genus Mus (Rodentia; Muridae). Molecular Biology and Evolution, 28(11), 2999-3003. doi:10.1093/molbev/msr150.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-EB60-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-EB61-9
Genre: Journal Article

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Linnenbrink_2011.pdf (Publisher version), 325KB
 
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 Creators:
Linnenbrink, Miriam, Author
Johnsen, Jill M., Author
Montero, Inka1, Author              
Brzezinski, Christine R., Author
Harr, Bettina1, Author              
Baines, John F.2, Author              
Affiliations:
1Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              
2Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445638              

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Free keywords: B4galnt2; balancing selection; Mus spretus; Mus musculus; blood group; von Willebrand disease
 Abstract: Recent surveys of the human genome have highlighted the significance of balancing selection in relation to understanding the evolutionary origins of disease-associated variation. Cis-regulatory variation at the blood group–related glycosyltransferase B4galnt2 is associated with a phenotype in mice that closely resembles a common human bleeding disorder, von Willebrand disease. In this study, we have performed a survey of the 5′ flanking region of the B4galnt2 gene in several Mus musculus subspecies and Mus spretus. Our results reveal a clear pattern of trans-species polymorphism and indicate that allele classes conferring alternative tissue-specific expression patterns have been maintained for >2.8 My in the genus Mus. Furthermore, analysis of B4galnt2 expression patterns revealed the presence of an additional functional class of alleles, supporting a role for gastrointestinal phenotypes in the long-term maintenance of expression variation at this gene.

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Language(s): eng - English
 Dates: 2011-06-072011-11
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1093/molbev/msr150
Other: 2881/S 39225
 Degree: -

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Title: Molecular Biology and Evolution
  Abbreviation : Mol. Biol. Evol.
Source Genre: Journal
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Publ. Info: Chicago, Ill. : University of Chicago Press
Pages: - Volume / Issue: 28 (11) Sequence Number: - Start / End Page: 2999 - 3003 Identifier: ISSN: 0737-4038 (print)
ISSN: 1537-1719 (online)
CoNE: /journals/resource/954925536119