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  Synthesis and characterization of RNA containing a rigid and nonperturbing cytidine-derived spin label.

Höbartner, C., Sicoli, G., Wachowius, F., Gophane, D. B., & Sigurdsson, S. T. (2012). Synthesis and characterization of RNA containing a rigid and nonperturbing cytidine-derived spin label. Journal of Organic Chemistry, 77(17), 7749-7754. doi:10.1021/jo301227w.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-EB8F-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-C65B-C
Genre: Journal Article

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1539257.pdf (Publisher version), 337KB
 
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http://pubs.acs.org/doi/pdf/10.1021/jo301227w (Publisher version)
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 Creators:
Höbartner, C.1, Author              
Sicoli, G.2, Author              
Wachowius, F.1, Author              
Gophane, D. B., Author
Sigurdsson, S. T., Author
Affiliations:
1Research Group of Nucleic Acid Chemistry, MPI for biophysical chemistry, Max Planck Society, ou_578605              
2Research Group of Electron Paramagnetic Resonance, MPI for biophysical chemistry, Max Planck Society, ou_578606              

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 Abstract: The nitroxide-containing nucleoside Çm is reported as the first rigid spin label for paramagnetic modification of RNA by solid-phase synthesis. The spin label is well accommodated in several RNA secondary structures as judged by its minor effect on the thermodynamic stability of hairpin and duplex RNA. Electron paramagnetic resonance (EPR) spectroscopic characterization of mono-, bi-, and trimolecular RNA structures shows that Çm will be applicable for advanced EPR studies to elucidate structural and dynamic aspects of folded RNA.

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Language(s): eng - English
 Dates: 2012-08-122012
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1021/jo301227w
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Title: Journal of Organic Chemistry
Source Genre: Journal
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Publ. Info: Washington, D.C., etc. : American Chemical Society [etc.]
Pages: - Volume / Issue: 77 (17) Sequence Number: - Start / End Page: 7749 - 7754 Identifier: ISSN: 0022-3263
CoNE: https://pure.mpg.de/cone/journals/resource/954925416967