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  The evolutionary emergence of stochastic phenotype switching in bacteria

Rainey, P. B., Beaumont, H. J., Ferguson, G. C., Gallie, J., Kost, C., Libby, E., et al. (2011). The evolutionary emergence of stochastic phenotype switching in bacteria. Microbial Cell Factories, 10(Suppl. 1): S 14. doi:10.1186/1475-2859-10-S1-S14.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-EBCA-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-07DC-A
Genre: Conference Paper

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 Creators:
Rainey, Paul B.1, Author              
Beaumont, Hubertus JE, Author
Ferguson, Gayle C, Author
Gallie, Jenna2, Author              
Kost, Christian, Author
Libby, Eric, Author
Zhang, Xue-Xian, Author
Affiliations:
1External Scientific Member Group Experimental and Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445637              
2External Organizations, ou_persistent22              

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 Abstract: Stochastic phenotype switching – or bet hedging – is a pervasive feature of living systems and common in bacteria that experience fluctuating (unpredictable) environmental conditions. Under such conditions, the capacity to generate variable offspring spreads the risk of being maladapted in the present environment, against offspring likely to have some chance of survival in the future. While a rich subject for theoretical studies, little is known about the selective causes responsible for the evolutionary emergence of stochastic phenotype switching. Here we review recent work – both theoretical and experimental – that sheds light on ecological factors that favour switching types over non-switching types. Of particular relevance is an experiment that provided evidence for an adaptive origin of stochastic phenotype switching by subjecting bacterial populations to a selective regime that mimicked essential features of the host immune response. Central to the emergence of switching types was frequent imposition of ‘exclusion rules’ and ‘population bottlenecks’ – two complementary faces of frequency dependent selection. While features of the immune response, exclusion rules and bottlenecks are likely to operate in many natural environments. Together these factors define a set of selective conditions relevant to the evolution of stochastic switching, including antigenic variation and bacterial persistence.

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Language(s): eng - English
 Dates: 2011-09-09
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
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 Identifiers: DOI: 10.1186/1475-2859-10-S1-S14
Other: 2891/S 39236
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Title: 10th Symposium on Lactic Acid Bacterium
Place of Event: Egmond aan Zee
Start-/End Date: 2011-08-28 - 2011-09-01

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Title: Microbial Cell Factories
Source Genre: Journal
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Publ. Info: BioMed Central, Proceedings
Pages: 7 p. Volume / Issue: 10 (Suppl. 1) Sequence Number: S 14 Start / End Page: - Identifier: ISSN: 1475-2859
CoNE: /journals/resource/111041294029026