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  Reciprocal gene loss following experimental whole-genome duplication causes reproductive isolation in yeast

MacLean, C. J., & Greig, D. (2011). Reciprocal gene loss following experimental whole-genome duplication causes reproductive isolation in yeast. Evolution, 65(4), 932-945. doi:10.1111/j.1558-5646.2010.01171.x.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-EBD3-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-EBD4-5
Genre: Journal Article

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Maclean_2011.pdf (Publisher version), 546KB
 
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 Creators:
MacLean, Callum J., Author
Greig, Duncan1, Author              
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1Max-Planck Research Group Experimental Evolution, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445640              

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Free keywords: Allotetraploid; divergent resolution; polyploidy; Saccharomyces; speciation
 Abstract: Whole-genome duplication has shaped the genomes of extant lineages ranging from unicellular fungi to vertebrates, and its association with several species-rich taxa has fuelled interest in its potential as a catalyst for speciation. One well-established model for the evolution of reproductive isolation involves the reciprocal loss of redundant genes at different loci in allopatric populations. Whole-genome duplication simultaneously doubles the entire gene content of an organism, resulting in massive levels of genetic redundancy and potential for reciprocal gene loss that may produce postzygotic reproductive isolation. Following whole-genome duplication, different populations can potentially change or lose gene function at different duplicate loci. If such populations come back into contact any F1 hybrids that are formed may suffer reduced fertility as some of the gametes they produce may not carry a full complement of functional genes. This reduction in hybrid fertility will be directly proportional to the number of divergently resolved loci between the populations. In this work, we demonstrate that initially identical populations of allotetraploid yeast subjected to mutagenesis rapidly evolve postzygotic reproductive isolation, consistent with the divergent loss of function of redundant gene copies.

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Language(s): eng - English
 Dates: 2010-03-052010-09-242011-04
 Publication Status: Published in print
 Pages: -
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 Rev. Method: -
 Identifiers: DOI: 10.1111/j.1558-5646.2010.01171.x
Other: 2834/S 39177
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Title: Evolution
  Other : Evolution
Source Genre: Journal
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Publ. Info: Boulder, Colo.? : Society for the Study of Evolution
Pages: - Volume / Issue: 65 (4) Sequence Number: - Start / End Page: 932 - 945 Identifier: ISSN: 0014-3820 (print)
ISSN: 1558-5646 (online)
CoNE: /journals/resource/991042730870254