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  Controlled enzyme-catalyzed degradation of polymeric capsules templated on CaCO3: Influence of the number of LbL layers, conditions of degradation, and disassembly of multicompartments.

Marchenko, I., Yashchenok, A., Borodina, T., Bukreeva, T., Konrad, M., Möhwald, H., et al. (2012). Controlled enzyme-catalyzed degradation of polymeric capsules templated on CaCO3: Influence of the number of LbL layers, conditions of degradation, and disassembly of multicompartments. Journal of Controlled Release, 162(3), 599-605. doi:10.1016/j.jconrel.2012.08.006.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-F108-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-CADE-6
Genre: Journal Article

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1546209.pdf (Publisher version), 528KB
 
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 Creators:
Marchenko, I., Author
Yashchenok, A., Author
Borodina, T., Author
Bukreeva, T., Author
Konrad, M.1, Author              
Möhwald, H., Author
Skirtach, A., Author
Affiliations:
1Research Group of Enzyme Biochemistry, MPI for biophysical chemistry, Max Planck Society, ou_578612              

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Free keywords: Microcapsules; Layer-by-layer; Drug delivery; Calcium carbonate; Controlled release
 Abstract: Enzyme-catalyzed degradation of CaCO3-templated capsules is presented. We investigate a) biodegradable, b) mixed biodegradable/synthetic, and c) multicompartment polyelectrolyte multilayer capsules with different numbers of polymer layers. Using confocal laser scanning microscopy we observed the kinetics of the non-specific protease Pronase-induced degradation of capsules is slowed down on the order of hours by either increasing the number of layers in the wall of biodegradable capsules, or by inserting synthetic polyelectrolyte multilayers into the shell comprised of biodegradable polymers. The degradation rate increases with the concentration of Pronase. Controlled detachment of subcompartments of multicompartment capsules, with potential for intracellular delivery or in-vivo applications, is also shown.

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Language(s): eng - English
 Dates: 2012-08-112012-09-28
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.jconrel.2012.08.006
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Title: Journal of Controlled Release
Source Genre: Journal
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Pages: - Volume / Issue: 162 (3) Sequence Number: - Start / End Page: 599 - 605 Identifier: -