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  Genomewide comparison of DNA sequences between humans and chimpanzees

Ebersberger, I., Metzler, D., Schwarz, C., & Pääbo, S. (2002). Genomewide comparison of DNA sequences between humans and chimpanzees. American Journal of Human Genetics, 70(6), 1490-1497. doi:10.1086/340787.

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 Creators:
Ebersberger, Ingo1, Author           
Metzler, Dirk1, Author           
Schwarz, Carsten2, 3, Author           
Pääbo, Svante1, Author                 
Affiliations:
1Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society, ou_1497672              
2Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society, ou_1497674              
3Department of Developmental and Comparative Psychology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society, ou_1497671              

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 Abstract: A total of 8,859 DNA sequences encompassing similar to1.9 million base pairs of the chimpanzee genome were sequenced and compared to corresponding human DNA sequences. Although the average sequence difference is low (1.24%), the extent of changes is markedly different among sites and types of substitutions. Whereas similar to15% of all CpG sites have experienced changes between humans and chimpanzees, owing to a 23-fold excess of transitions and a 7-fold excess of transversions, substitutions at other sites vary in frequency, between 0.1% and 0.5%. If the nucleotide diversity in the common ancestral species of humans and chimpanzees is assumed to have been about fourfold higher than in contemporary humans, all possible comparisons between autosomes and X and Y chromosomes result in estimates of the ratio between male and female mutation rates of similar to3. Thus, the relative time spent in the male and female germlines may be a major determinant of the overall accumulation of nucleotide substitutions. However, since the extent of divergence differs significantly among autosomes, additional unknown factors must also influence the accumulation of substitutions in the human genome.

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Language(s): eng - English
 Dates: 2007-10-252002-06
 Publication Status: Issued
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 21678
DOI: 10.1086/340787
ISI: 000175445700010
 Degree: -

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Title: American Journal of Human Genetics
  Alternative Title : Am. J. Hum. Genet.
Source Genre: Journal
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Pages: - Volume / Issue: 70 (6) Sequence Number: - Start / End Page: 1490 - 1497 Identifier: ISSN: 0002-9297