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  Evolutionary dynamics of mutations in hematopoietic stem cells and beyond

Dingli, D., Traulsen, A., & Pacheco, J. M. (2012). Evolutionary dynamics of mutations in hematopoietic stem cells and beyond. In Stem Cells and Cancer Stem Cells (pp. 115-123). Dordrecht, Heidelberg, London New York: Springer.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-0CF4-E Version Permalink: http://hdl.handle.net/21.11116/0000-0003-3AA0-7
Genre: Book Chapter

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Dingli_Springer_2012.pdf (Publisher version), 823KB
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 Creators:
Dingli, David, Author
Traulsen, Arne1, Author              
Pacheco, Jorge M., Author
Affiliations:
1Research Group Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445641              

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Free keywords: hematopoiesis; mutations; retroviruses; neutrophils; apoptosis; CFU
 Abstract: Mutations are a natural consequence of the interactions of our genome with genotoxic agents and imperfections in the DNA replication machinery. Every cell is at risk of mutations and therefore the probability of acquiring mutations is increasing with population size. However, the impact of a mutation depends on the type of cell where it occurs and the average lifetime of that cell. Tissue architecture is organized in such a way that many mutations will have no consequence, although the cell harboring them may expand into a detectable clone. We will use the known architecture and dynamics of hematopoiesis to describe the evolution of mutant clones in age structured populations and show why the appearance of well recognized mutations is inevitable even if usually of no consequence. Most mutant populations merely cause transient ripples in a tissue. However, whenever mutations occur in stem cells or other primitive cells, the associated clones can have long lasting consequences and may lead to disease.

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Language(s): eng - English
 Dates: 2012
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: Other: 2956/S 39301
 Degree: -

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Title: Stem Cells and Cancer Stem Cells
Source Genre: Book
 Creator(s):
Hayat, M. A., Author
Affiliations:
-
Publ. Info: Dordrecht, Heidelberg, London New York : Springer
Pages: XXVII, 398 p. Volume / Issue: 3 Sequence Number: - Start / End Page: 115 - 123 Identifier: ISBN: 978-94-007-2414-3