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  Statistics of divergence times

Haubold, B., & Wiehe, T. (2001). Statistics of divergence times. Molecular Biology and Evolution, 18(7), 1157-1160.

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資料種別: 学術論文

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 作成者:
Haubold, B.1, 著者           
Wiehe, T.2, 著者
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1External, ou_persistent22              
2external, ou_persistent22              

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 要旨: Given the number of nucleotide substitutions between two species (K) and the substitution rate nu, the expectation of the corresponding divergence time is usually calculated as K/(2 nu). This is strictly true only if nu is regarded as a constant because the ratio of two random variables, such as K/(2 nu), has distributional properties different from those of the distribution of K. Therefore, both the mean and any confidence interval for divergence times are unknown in this situation. We model the distribution of K and nu using the Gamma distribution and calculate the mean and 95% confidence interval for the corresponding divergence time. These calculations are compared with results obtained by bootstrapping sequence data from the model plant Arabidopsis thaliana and its relatives. We show that for nonoverlapping pairs of phylogenetic distances, our method approaches the bootstrap results very closely. In contrast, regarding the mutation rate as a constant leads to strong underestimation of the confidence interval. An implementation of our method of computing divergence times is accessible through a web interface at http://www.soft.ice.mpg.de/cite.

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 日付: 2001-072001-07
 出版の状態: 出版
 ページ: -
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 識別子(DOI, ISBNなど): ISI: 000169846400001
 学位: -

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出版物名: Molecular Biology and Evolution
種別: 学術雑誌
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出版社, 出版地: Chicago, Ill. : University of Chicago Press
ページ: - 巻号: 18 (7) 通巻号: - 開始・終了ページ: 1157 - 1160 識別子(ISBN, ISSN, DOIなど): ISSN: 0737-4038 (print)
ISSN: 1537-1719 (online)