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  Deep-brain-stimulation does not impair deglutition in Parkinson's disease

Lengerer, S., Kipping, J., Rommel, N., Weiss, D., Breit, S., Gasser, T., et al. (2012). Deep-brain-stimulation does not impair deglutition in Parkinson's disease. Parkinsonism & Related Disorders, 18(7), 847-853. doi:10.1016/j.parkreldis.2012.04.014.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-150D-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-5C2F-2
Genre: Journal Article

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Lengerer_2012_Deep-brain-stimulation.pdf (Publisher version), 676KB
 
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 Creators:
Lengerer, Sabrina1, Author
Kipping, Judy2, 3, Author              
Rommel, Natalie4, Author
Weiss, Daniel1, 2, Author
Breit, Sorin1, 2, Author
Gasser, Thomas1, 2, Author
Plewnia, Christian5, Author
Krüger, Rejko1, 2, Author
Wächter, Tobias1, 2, Author
Affiliations:
1German Center for Neurodegenerative Diseases, Tübingen, Germany, ou_persistent22              
2Hertie-Institute for Clinical Brain Research, Eberhard Karls University Tübingen, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
4Therapiezentrum, Eberhard Karls University Tübingen, Germany, ou_persistent22              
5Department for Psychiatry and Psychotherapy, Eberhard Karls University Tübingen, Germany, ou_persistent22              

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Free keywords: Parkinson; Deep-brain-stimulation; Dysphagia; Nucleus subthalamicus; Swallowing
 Abstract: Objective A large proportion of patients with Parkinson's disease develop dysphagia during the course of the disease. Dysphagia in Parkinson's disease affects different phases of deglutition, has a strong impact on quality of life and may cause severe complications, i.e. aspirational pneumonia. So far, little is known on how deep-brain-stimulation of the subthalamic nucleus influences deglutition in PD. Methods Videofluoroscopic swallowing studies on 18 patients with Parkinson's disease, which had been performed preoperatively, and postoperatively with deep-brain-stimulation-on and deep-brain-stimulation-off, were analyzed retrospectively. The patients were examined in each condition with three consistencies (viscous, fluid and solid). The ‘New Zealand Index for Multidisciplinary Evaluation of Swallowing (NZIMES) Subscale One’ for qualitative and ‘Logemann-MBS-Parameters’ for quantitative evaluation were assessed. Results Preoperatively, none of the patients presented with clinically relevant signs of dysphagia. While postoperatively, the mean daily levodopa equivalent dosage was reduced by 50% and deep-brain-stimulation led to a 50% improvement in motor symptoms measured by the UPDRS III, no clinically relevant influence of deep-brain-stimulation-on swallowing was observed using qualitative parameters (NZIMES). However quantitative parameters (Logemann scale) found significant changes of pharyngeal parameters with deep-brain-stimulation-on as compared to preoperative condition and deep-brain-stimulation-off mostly with fluid consistency. Conclusion In Parkinson patients without dysphagia deep-brain-stimulation of the subthalamic nucleus modulates the pharyngeal deglutition phase but has no clinically relevant influence on deglutition. Further studies are needed to test if deep-brain-stimulation is a therapeutic option for patients with swallowing disorders.

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Language(s): eng - English
 Dates: 2012-04-102012-05-162012-08
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.parkreldis.2012.04.014
PMID: 22608093
Other: Epub 2012
 Degree: -

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Title: Parkinsonism & Related Disorders
Source Genre: Journal
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Publ. Info: Kiddlington, Oxford, U.K. : Elsevier
Pages: - Volume / Issue: 18 (7) Sequence Number: - Start / End Page: 847 - 853 Identifier: ISSN: 1353-8020
CoNE: https://pure.mpg.de/cone/journals/resource/954925618102