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  Identifying the neural correlates of executive functions in early cerebral microangiopathy: A combined VBM and DTI study

Quinque, E. M., Arélin, K., Dukart, J., Roggenhofer, E., Streitbürger, D. P., Villringer, A., et al. (2012). Identifying the neural correlates of executive functions in early cerebral microangiopathy: A combined VBM and DTI study. Journal of Cerebral Blood Flow and Metabolism, 32(10), 1869-1878. doi:10.1038/jcbfm.2012.96.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-1537-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-B12C-4
Genre: Journal Article

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 Creators:
Quinque, Eva Maria1, Author              
Arélin, Katrin1, 2, 3, Author              
Dukart, Jürgen3, 4, Author
Roggenhofer, Elisabeth1, 2, 5, Author              
Streitbürger, Daniel Paolo6, Author              
Villringer, Arno1, 2, 3, Author              
Frisch, Stefan1, 7, Author              
Mueller, Karsten6, Author              
Schroeter, Matthias1, 2, 3, 8, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
3Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
4Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
5Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
6Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
7Department of Neurology, Goethe University, Frankfurt, Germany, ou_persistent22              
8Consortium for Frontotemporal Lobar Degeneration, Ulm, Germany, ou_persistent22              

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Free keywords: Cerebrovascular disease; Diffusion tensor imaging; MRI; Vascular cognitive impairment; White matter disease
 Abstract: Cerebral microangiopathy (CMA) has been associated with executive dysfunction and fronto-parietal neural network disruption. Advances in magnetic resonance imaging allow more detailed analyses of gray (e.g., voxel-based morphometry—VBM) and white matter (e.g., diffusion tensor imaging—DTI) than traditional visual rating scales. The current study investigated patients with early CMA and healthy control subjects with all three approaches. Neuropsychological assessment focused on executive functions, the cognitive domain most discussed in CMA. The DTI and age-related white matter changes rating scales revealed convergent results showing widespread white matter changes in early CMA. Correlations were found in frontal and parietal areas exclusively with speeded, but not with speed-corrected executive measures. The VBM analyses showed reduced gray matter in frontal areas. All three approaches confirmed the hypothesized fronto-parietal network disruption in early CMA. Innovative methods (DTI) converged with results from conventional methods (visual rating) while allowing greater spatial and tissue accuracy. They are thus valid additions to the analysis of neural correlates of cognitive dysfunction. We found a clear distinction between speeded and nonspeeded executive measures in relationship to imaging parameters. Cognitive slowing is related to disease severity in early CMA and therefore important for early diagnostics.

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Language(s): eng - English
 Dates: 2012-07-112012-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/jcbfm.2012.96
PMID: 22781332
PMC: PMC3463884
Other: Epub 2012
 Degree: -

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Title: Journal of Cerebral Blood Flow and Metabolism
Source Genre: Journal
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Publ. Info: New York : Lippincott Williams & Wilkins
Pages: - Volume / Issue: 32 (10) Sequence Number: - Start / End Page: 1869 - 1878 Identifier: ISSN: 0271-678X
CoNE: /journals/resource/954925503202