English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Cerebral blood volume changes during brain activation

Krieger, S., Streicher, M., Trampel, R., & Turner, R. (2012). Cerebral blood volume changes during brain activation. Journal of Cerebral Blood Flow and Metabolism, 32(8), 1618-1631. doi:10.1038/jcbfm.2012.63.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-164B-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-5C30-F
Genre: Journal Article

Files

show Files
hide Files
:
Krieger_2012_Cerebral.pdf (Publisher version), 809KB
 
File Permalink:
-
Name:
Krieger_2012_Cerebral.pdf
Description:
-
Visibility:
Private
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Krieger, Steffen1, Author              
Streicher, Markus1, Author              
Trampel, Robert1, Author              
Turner, Robert1, Author              
Affiliations:
1Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              

Content

show
hide
Free keywords: Blood–brain barrier; Capillaries; Cerebral blood flow; Cerebral hemodynamics; Mathematical modeling; Physiology
 Abstract: Cerebral blood volume (CBV) changes significantly with brain activation, whether measured using positron emission tomography, functional magnetic resonance imaging (fMRI), or optical microscopy. If cerebral vessels are considered to be impermeable, the contents of the skull incompressible, and the skull itself inextensible, task- and hypercapnia-related changes of CBV could produce intolerable changes of intracranial pressure. Because it is becoming clear that CBV may be useful as a well-localized marker of neural activity changes, a resolution of this apparent paradox is needed. We have explored the idea that much of the change in CBV is facilitated by exchange of water between capillaries and surrounding tissue. To this end, we developed a novel hemodynamic boundary-value model and found approximate solutions using a numerical algorithm. We also constructed a macroscopic experimental model of a single capillary to provide biophysical insight. Both experiment and theory model capillary membranes as elastic and permeable. For a realistic change of input pressure, a relative pipe volume change of 21±5% was observed when using the experimental setup, compared with the value of approximately 17±1% when this quantity was calculated from the mathematical model. Volume, axial flow, and pressure changes are in the expected range.

Details

show
hide
Language(s): eng - English
 Dates: 2012-05-092012-08-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/jcbfm.2012.63
PMID: 22569192
PMC: PMC3421101
Other: Epub 2012
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Journal of Cerebral Blood Flow and Metabolism
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York : Lippincott Williams & Wilkins
Pages: - Volume / Issue: 32 (8) Sequence Number: - Start / End Page: 1618 - 1631 Identifier: ISSN: 0271-678X
CoNE: https://pure.mpg.de/cone/journals/resource/954925503202