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  Cerebral blood volume changes during brain activation

Krieger, S., Streicher, M., Trampel, R., & Turner, R. (2012). Cerebral blood volume changes during brain activation. Journal of Cerebral Blood Flow and Metabolism, 32(8), 1618-1631. doi:10.1038/jcbfm.2012.63.

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Krieger_2012_Cerebral.pdf (Verlagsversion), 809KB
 
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 Urheber:
Krieger, Steffen1, Autor           
Streicher, Markus1, Autor           
Trampel, Robert1, Autor           
Turner, Robert1, Autor           
Affiliations:
1Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              

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Schlagwörter: Blood–brain barrier; Capillaries; Cerebral blood flow; Cerebral hemodynamics; Mathematical modeling; Physiology
 Zusammenfassung: Cerebral blood volume (CBV) changes significantly with brain activation, whether measured using positron emission tomography, functional magnetic resonance imaging (fMRI), or optical microscopy. If cerebral vessels are considered to be impermeable, the contents of the skull incompressible, and the skull itself inextensible, task- and hypercapnia-related changes of CBV could produce intolerable changes of intracranial pressure. Because it is becoming clear that CBV may be useful as a well-localized marker of neural activity changes, a resolution of this apparent paradox is needed. We have explored the idea that much of the change in CBV is facilitated by exchange of water between capillaries and surrounding tissue. To this end, we developed a novel hemodynamic boundary-value model and found approximate solutions using a numerical algorithm. We also constructed a macroscopic experimental model of a single capillary to provide biophysical insight. Both experiment and theory model capillary membranes as elastic and permeable. For a realistic change of input pressure, a relative pipe volume change of 21±5% was observed when using the experimental setup, compared with the value of approximately 17±1% when this quantity was calculated from the mathematical model. Volume, axial flow, and pressure changes are in the expected range.

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Sprache(n): eng - English
 Datum: 2012-05-092012-08-01
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1038/jcbfm.2012.63
PMID: 22569192
PMC: PMC3421101
Anderer: Epub 2012
 Art des Abschluß: -

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Titel: Journal of Cerebral Blood Flow and Metabolism
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: New York : Lippincott Williams & Wilkins
Seiten: - Band / Heft: 32 (8) Artikelnummer: - Start- / Endseite: 1618 - 1631 Identifikator: ISSN: 0271-678X
CoNE: https://pure.mpg.de/cone/journals/resource/954925503202