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  Layer-specific intracortical connectivity revealed with Diffusion MRI

Leuze, C., Anwander, A., Bazin, P.-L., Dhital, B., Stüber, C., Reimann, K., et al. (2014). Layer-specific intracortical connectivity revealed with Diffusion MRI. Cerebral Cortex, 24(2), 328-339. doi:10.1093/cercor/bhs311.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-16CE-A Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7EA7-4
Genre: Journal Article

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 Creators:
Leuze, Christoph1, Author              
Anwander, Alfred2, Author              
Bazin, Pierre-Louis1, 3, Author              
Dhital, Bibek1, Author              
Stüber, Carsten1, Author              
Reimann, Katja1, Author              
Geyer, Stefan1, Author              
Turner, Robert1, Author              
Affiliations:
1Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              

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Free keywords: Crossing-fiber tractography; Diffusion tensor imaging; Layer 1; Stria of Gennari; Visual cortex
 Abstract: In this work, we show for the first time that the tangential diffusion component is orientationally coherent at the human cortical surface. Using diffusion magnetic resonance imaging (dMRI), we have succeeded in tracking intracortical fiber pathways running tangentially within the cortex. In contrast with histological methods, which reveal little regarding 3-dimensional organization in the human brain, dMRI delivers additional understanding of the layer dependence of the fiber orientation. A postmortem brain block was measured at very high angular and spatial resolution. The dMRI data had adequate resolution to allow analysis of the fiber orientation within 4 notional cortical laminae. We distinguished a lamina at the cortical surface where diffusion was tangential along the surface, a lamina below the surface where diffusion was mainly radial, an internal lamina covering the Stria of Gennari, where both strong radial and tangential diffusion could be observed, and a deep lamina near the white matter, which also showed mainly radial diffusion with a few tangential compartments. The measurement of the organization of the tangential diffusion component revealed a strong orientational coherence at the cortical surface.

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Language(s): eng - English
 Dates: 2012-10-252014-02
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1093/cercor/bhs311
PMID: 23099298
PMC: PMC3888365
Other: Epub 2012
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Title: Cerebral Cortex
Source Genre: Journal
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Pages: - Volume / Issue: 24 (2) Sequence Number: - Start / End Page: 328 - 339 Identifier: ISSN: 1047-3211
CoNE: /journals/resource/954925592440