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  Emerging views about the molecular structure of the spliceosomal catalytic center.

Schmitzova, J., & Pena, V. (2012). Emerging views about the molecular structure of the spliceosomal catalytic center. RNA Biology, 9(11), 1311-1318. doi:10.4161/rna.22359.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-19E7-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-189A-6
Genre: Journal Article

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1564000.pdf (Publisher version), 2MB
 
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 Creators:
Schmitzova, J.1, Author              
Pena, V.2, Author              
Affiliations:
1Department of Cellular Biochemistry, MPI for biophysical chemistry, Max Planck Society, ou_578576              
2Research Group of Macromolecular Crystallography, MPI for Biophysical Chemistry, Max Planck Society, ou_2035293              

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Free keywords: Spliceosome, group II introns, splicing catalysis, RNA tertiary interactions, Cwc2, Prp8, RNA splicing, U6-ISL, Domain V, RNA-protein interaction
 Abstract: Pre-mRNA splicing occurs in two chemical steps that are catalyzed by a large, dynamic RNA-protein complex called the spliceosome. Initially assembled in a catalytically inactive form, the spliceosome undergoes massive compositional and conformational remodeling, through which disparate RNA elements are re-configured and juxtaposed into a functional catalytic center. The intricate construction of the catalytic center requires the assistance of spliceosomal proteins. Recent structure-function analyses have demonstrated that the yeast-splicing factor Cwc2 is a main player that contacts and shapes the catalytic center of the spliceosome into a functional conformation. With this advance, corroborated by the atomic structure of the evolutionarily related group IIC introns, our understanding of the organization and formation of the spliceosomal catalytic center has progressed to a new level.

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Language(s): eng - English
 Dates: 2012-11
 Publication Status: Published online
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 Rev. Method: Peer
 Identifiers: DOI: 10.4161/rna.22359
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Title: RNA Biology
Source Genre: Journal
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Pages: - Volume / Issue: 9 (11) Sequence Number: - Start / End Page: 1311 - 1318 Identifier: -