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  CNTNAP2 and language processing in healthy individuals as measured with ERPs

Kos, M., Van den Brink, D., Snijders, T. M., Rijpkema, M., Franke, B., Fernandez, G., Hagoort, P., & Whitehouse, A. (2012). CNTNAP2 and language processing in healthy individuals as measured with ERPs. PLoS One, 7(10), e46995. doi:10.1371/journal.pone.0046995.

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資料種別: 学術論文

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Kos_PLoS_2012.pdf (出版社版), 372KB
ファイルのパーマリンク:
https://hdl.handle.net/11858/00-001M-0000-0010-1C63-6
ファイル名:
Kos_PLoS_2012.pdf
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公開
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application/pdf / [MD5]
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-
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2012 Kos et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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 作成者:
Kos, Miriam1, 著者
Van den Brink, Daniëlle1, 2, 著者           
Snijders, Tineke M.1, 3, 4, 著者           
Rijpkema, Mark1, 著者
Franke, Barbara1, 5, 6, 著者
Fernandez, Guillen1, 7, 著者
Hagoort, Peter1, 2, 8, 著者           
Whitehouse, Andrew9, 著者
所属:
1Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands, ou_persistent22              
2Radboud University Nijmegen, Behavioural Science Institute, Nijmegen, The Netherlands, ou_persistent22              
3Department of Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, The Netherlands, ou_persistent22              
4Rudolf Magnus Institute of Neuroscience, Department of Child and Adolescent Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands, ou_persistent22              
5Department of Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, ou_persistent22              
6Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, ou_persistent22              
7Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, ou_persistent22              
8Neurobiology of Language Department, MPI for Psycholinguistics, Max Planck Society, ou_792551              
9The University of Western Australia, Australia, ou_persistent22              

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 要旨: The genetic FOXP2-CNTNAP2 pathway has been shown to be involved in the language capacity. We investigated whether a common variant of CNTNAP2 (rs7794745) is relevant for syntactic and semantic processing in the general population by using a visual sentence processing paradigm while recording ERPs in 49 healthy adults. While both AA homozygotes and T-carriers showed a standard N400 effect to semantic anomalies, the response to subject-verb agreement violations differed across genotype groups. T-carriers displayed an anterior negativity preceding the P600 effect, whereas for the AA group only a P600 effect was observed. These results provide another piece of evidence that the neuronal architecture of the human faculty of language is shaped differently by effects that are genetically determined.

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言語: eng - English
 日付: 2012-10-24
 出版の状態: オンラインで出版済み
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子(DOI, ISBNなど): DOI: 10.1371/journal.pone.0046995
 学位: -

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出版物 1

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出版物名: PLoS One
種別: 学術雑誌
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出版社, 出版地: San Francisco, CA : Public Library of Science
ページ: - 巻号: 7 (10) 通巻号: - 開始・終了ページ: e46995 識別子(ISBN, ISSN, DOIなど): ISSN: 1932-6203
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000277850