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  Changes to the fractional anisotropy & mean diffusivity of in vivo rat brain measured at short effective diffusion-times

Kershaw, J., Leuze, C., Obata, T., Kanno, I., & Aoki, I. (2011). Changes to the fractional anisotropy & mean diffusivity of in vivo rat brain measured at short effective diffusion-times. Talk presented at 19th Annual Meeting of the International Society for Magnetic Resonance in Medicine. Montreal, QC, Canada. 2011-05-07 - 2011-05-13.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-2121-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-C045-1
Genre: Talk

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 Creators:
Kershaw, Jeff1, 2, Author
Leuze, Christoph3, Author              
Obata, Takayuki1, Author
Kanno, Iwao1, Author
Aoki, Ichio1, Author
Affiliations:
1National Institute of Radiological Sciences, Chiba, Japan, ou_persistent22              
2School of Bioscience & Biotechnology, Tokyo Institute of Technology, Yokohama, Japan, ou_persistent22              
3Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              

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 Abstract: A sequence with oscillating motion-probing gradients was applied to investigate the restricted or hindered motion of water in in vivo rat brain tissue by observing changes to the apparent diffusion tensor, fractional anisotropy (FA) and mean diffusivity (MD) as the effective diffusion-time is decreased. Imaging was performed in a sagittal slice through the rat cerebellum and corpus callosum, which contain most of the white matter in the rat brain. Paired-t tests found significant differences in the FA of the corpus callosum and cerebellar white matter after the effective diffusion-time was decreased from 7.5 ms to 3.75 ms. Significant differences were also found for the MD in both grey and white matter. It is anticipated that normal and pathological in vivo tissue structure can be probed with this technique.

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 Dates: 2011-05-11
 Publication Status: Not specified
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Title: 19th Annual Meeting of the International Society for Magnetic Resonance in Medicine
Place of Event: Montreal, QC, Canada
Start-/End Date: 2011-05-07 - 2011-05-13

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