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  Cerebellar transcranial direct current stimulation modulates verbal working memory

Böhringer, A., Macher, K., Dukart, J., Villringer, A., & Pleger, B. (2013). Cerebellar transcranial direct current stimulation modulates verbal working memory. Brain Stimulation, 6(4), 649-653. doi:10.1016/j.brs.2012.10.001.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-233C-B Version Permalink: http://hdl.handle.net/21.11116/0000-0003-8CBB-D
Genre: Journal Article

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 Creators:
Böhringer, Andreas1, 2, Author              
Macher, Katja1, Author              
Dukart, Jürgen1, 3, Author              
Villringer, Arno1, 4, 5, Author              
Pleger, Burkhard1, 5, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Central Institute of Mental Health, Mannheim, Germany, ou_persistent22              
3Département des Neurosciences Cliniques, Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
4Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
5Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

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Free keywords: Cerebellum, tDCS, Working memory, Digit span
 Abstract: Background Neuroimaging studies show cerebellar activations in a wide range of cognitive tasks and patients with cerebellar lesions often present cognitive deficits suggesting a cerebellar role in higher-order cognition. Objective We used cathodal transcranial direct current stimulation (tDCS), known to inhibit neuronal excitability, over the cerebellum to investigate if cathodal tDCS impairs verbal working memory, an important higher-order cognitive faculty. Method We tested verbal working memory as measured by forward and backward digit spans in 40 healthy young participants before and after applying cathodal tDCS (2 mA, stimulation duration 25 min) to the right cerebellum using a randomized, sham-controlled, double-blind, cross-over design. In addition, we tested the effect of cerebellar tDCS on word reading, finger tapping and a visually cued sensorimotor task. Results In line with lower digit spans in patients with cerebellar lesions, cerebellar tDCS reduced forward digit spans and blocked the practice dependent increase in backward digit spans. No effects of tDCS on word reading, finger tapping or the visually cued sensorimotor task were found. Conclusion Our results support the view that the cerebellum contributes to verbal working memory as measured by forward and backward digit spans. Moreover, the induction of reversible “virtual cerebellar lesions” in healthy individuals by means of tDCS may improve our understanding of the mechanistic basis of verbal working memory deficits in patients with cerebellar lesions.

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Language(s): eng - English
 Dates: 2012-10-032012-06-302012-10-042012-10-272013-07
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.brs.2012.10.001
PMID: 23122917
Other: Epub 2012
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Title: Brain Stimulation
  Abbreviation : Brain Stimul
Source Genre: Journal
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Publ. Info: New York, NY : Elsevier
Pages: - Volume / Issue: 6 (4) Sequence Number: - Start / End Page: 649 - 653 Identifier: ISSN: 1935-861X
CoNE: https://pure.mpg.de/cone/journals/resource/1935-861X