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  Divergent Total Synthesis of the Antimitotic Agent Leiodermatolide

Willwacher, J., Kausch-Busies, N., & Fürstner, A. (2012). Divergent Total Synthesis of the Antimitotic Agent Leiodermatolide. Angewandte Chemie International Edition, 51(48), 12041-12046. doi:10.1002/anie.201206670.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-2562-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-300D-2
Genre: Journal Article

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[300]SI.pdf (Supplementary material), 8MB
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[300]SI.pdf
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Supporting Information
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Copyright Date:
2012
Copyright Info:
Wiley-VCH, 69451 Weinheim, Germany
License:
-

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 Creators:
Willwacher, Jens1, Author              
Kausch-Busies, Nina1, Author              
Fürstner, Alois1, Author              
Affiliations:
1Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445584              

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Free keywords: alkyne metathesis; antitumor agents; natural products; structure eludication; total synthesis
 Abstract: Subtle but distinctive: The stereostructure of the biologically highly promising antimitotic agent leiodermatolide was uncertain. A short, efficient, and flexible total synthesis based on ring-closing alkyne metathesis as the key step has now solved the puzzle. Subtle differences in the 1H NMR spectra of the structure shown and the conceivable isomer proved invaluable for the assignment.

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Language(s): eng - English
 Dates: 2012-10-182012-11-26
 Publication Status: Published in print
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/anie.201206670
 Degree: -

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Title: Angewandte Chemie International Edition
  Other : Angewandte Chemie International Edition in English
  Other : Angewandte Chemie - International Edition
  Abbreviation : Angew. Chem. Int. Ed.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Weinheim : Wiley-VCH
Pages: 6 Volume / Issue: 51 (48) Sequence Number: - Start / End Page: 12041 - 12046 Identifier: ISSN: 1433-7851
CoNE: https://pure.mpg.de/cone/journals/resource/201310171