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  A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light.

Albrecht, U., Sun, Z. S., Eichele, G., & Lee, C. C. (1997). A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light. Cell, 91(7), 1055-1064. doi:10.1016/S0092-8674(00)80495-X.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-4A70-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-C4C6-8
Genre: Journal Article

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1577226.pdf (Publisher version), 2MB
 
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 Creators:
Albrecht, U., Author
Sun, Z. S., Author
Eichele, G.1, Author              
Lee, C. C., Author
Affiliations:
1Department of Molecular Embryology, Max Planck Institute for Experimental Endocrinology, Max Planck Society, ou_1565140              

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 Abstract: A mouse gene, mper1, having all the properties expected of a circadian clock gene, was reported recently. This gene is expressed in a circadian pattern in the suprachiasmatic nucleus (SCN). mper1 maintains this pattern of circadian expression in constant darkness and can be entrained to a new light/dark cycle. Here we report the isolation of a second mammalian gene, mper2, which also has these properties and greater homology to Drosophila period. Expression of mper1 and mper2 is overlapping but asynchronous by 4 hr. mper1, unlike period and mper2, is expressed rapidly after exposure to light at CT22. It appears that mper1 is the pacemaker component which responds to light and thus mediates photic entrainment.

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Language(s): eng - English
 Dates: 1997-12-26
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1016/S0092-8674(00)80495-X
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Title: Cell
Source Genre: Journal
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Pages: - Volume / Issue: 91 (7) Sequence Number: - Start / End Page: 1055 - 1064 Identifier: -