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  RIGUI, a putative mammalian ortholog of the Drosophila period gene.

Sun, Z. S., Albrecht, U., Zhuchenko, O., Bailey, J., Eichele, G., & Lee, C. C. (1997). RIGUI, a putative mammalian ortholog of the Drosophila period gene. Cell, 90(6), 1003-1011. doi:10.1016/S0092-8674(00)80366-9.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-4A79-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-C4C7-6
Genre: Journal Article

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1577231.pdf (Publisher version), 3MB
 
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 Creators:
Sun, Z. S., Author
Albrecht, U., Author
Zhuchenko, O., Author
Bailey, J., Author
Eichele, G.1, Author              
Lee, C. C., Author
Affiliations:
1Department of Molecular Embryology, Max Planck Institute for Experimental Endocrinology, Max Planck Society, ou_1565140              

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 Abstract: The molecular components of mammalian circadian clocks are elusive. We have isolated a human gene termed RIGUI that encodes a bHLH/PAS protein 44% homologous to Drosophila period. The highly conserved mouse homolog (m-rigui) is expressed in a circadian pattern in the suprachiasmatic nucleus (SCN), the master regulator of circadian clocks in mammals. Circadian expression in the SCN continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of m-rigui expression in the SCN. m-rigui transcripts also appear in a periodic pattern in Purkinje neurons, pars tuberalis, and retina, but with a timing of oscillation different from that seen in the SCN. Sequence homology and circadian patterns of expression suggest that RIGUI is a mammalian ortholog of the Drosophila period gene, raising the possibility that a regulator of circadian clocks is conserved.

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Language(s): eng - English
 Dates: 1997-09-19
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1016/S0092-8674(00)80366-9
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Title: Cell
Source Genre: Journal
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Pages: - Volume / Issue: 90 (6) Sequence Number: - Start / End Page: 1003 - 1011 Identifier: -