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  Whole-genome sequencing of multiple Arabidopsis thaliana populations

Cao, J., Schneeberger, K., Ossowski, S., Günther, T., Bender, S., Fitz, J., et al. (2011). Whole-genome sequencing of multiple Arabidopsis thaliana populations. Nature Genetics, 43(10), 956-963. doi:10.1038/ng.911.

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Datensatz-Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-4C34-2 Versions-Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-0BA5-2
Genre: Zeitschriftenartikel

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Cao, J., Autor
Schneeberger, K., Autor
Ossowski, S., Autor
Günther, T., Autor
Bender, S., Autor
Fitz, J., Autor
Koenig, D., Autor
Lanz, C., Autor
Stegle, O.1, Autor              
Lippert, C.2, Autor
Wang, X.3, Autor              
Ott, F., Autor
Müller, J.4, Autor              
Alonso-Blanco, C., Autor
Borgwardt, K.1, 5, Autor              
Schmid, K. J., Autor
Weigel, D.6, Autor              
Affiliations:
1Research Group Machine Learning and Computational Biology, Max Planck Institute for Intelligent Systems, Max Planck Society, ou_1497664              
2Max Planck Society, ou_persistent13              
3Former Dept. Theory of Mesoscopic Phenomena, Max Planck Institute for Intelligent Systems, Max Planck Society, ou_1497656              
4Dept. Theory of Inhomogeneous Condensed Matter, Max Planck Institute for Intelligent Systems, Max Planck Society, ou_1497643              
5Dept. Empirical Inference, Max Planck Institute for Intelligent Systems, Max Planck Society, ou_1497647              
6Dept. Metastable and Low-Dimensional Materials, Max Planck Institute for Intelligent Systems, Max Planck Society, ou_1497645              

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Schlagwörter: MPI für Intelligente Systeme; Abt. Schölkopf;
 Zusammenfassung: The plant Arabidopsis thaliana occurs naturally in many different habitats throughout Eurasia. As a foundation for identifying genetic variation contributing to adaptation to diverse environments, a 1001 Genomes Project to sequence geographically diverse A. thaliana strains has been initiated. Here we present the first phase of this project, based on population-scale sequencing of 80 strains drawn from eight regions throughout the species' native range. We describe the majority of common small-scale polymorphisms as well as many larger insertions and deletions in the A. thaliana pan-genome, their effects on gene function, and the patterns of local and global linkage among these variants. The action of processes other than spontaneous mutation is identified by comparing the spectrum of mutations that have accumulated since A. thaliana diverged from its closest relative 10 million years ago with the spectrum observed in the laboratory. Recent species-wide selective sweeps are rare, and potentially deleterious mutations are more common in marginal populations.

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 Datum: 2011-10-01
 Publikationsstatus: Im Druck publiziert
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: eDoc: 596134
URI: http://www.kyb.tuebingen.mpg.de/
Anderer: CaoSOGBFKLSLWOMABSW2012
DOI: 10.1038/ng.911
 Art des Abschluß: -

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Titel: Nature Genetics
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: -956 Band / Heft: 43 (10) Artikelnummer: - Start- / Endseite: 956 - 963 Identifikator: -