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  MyD88-deficient Hydra reveal an ancient function of TLR signaling in sensing bacterial colonizers

Franzenburg, S., Fraune, S., Künzel, S., Baines, J. F., Domazet-Lošo, T., & Bosch, T. C. G. (2012). MyD88-deficient Hydra reveal an ancient function of TLR signaling in sensing bacterial colonizers. Proceedings of the National Academy of Sciences of the United States of America, 109(47), 19374-19379. doi:10.1073/pnas.1213110109.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-5030-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-3922-7
Genre: Journal Article

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 Creators:
Franzenburg, Sören, Author
Fraune, Sebastian, Author
Künzel, Sven1, Author              
Baines, John F.2, Author              
Domazet-Lošo, Tomislav1, Author              
Bosch, Thomas C. G., Author
Affiliations:
1Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              
2Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445638              

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 Abstract: Toll-like receptor (TLR) signaling is one of the most important signaling cascades of the innate immune system of vertebrates. Studies in invertebrates have focused on the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans, and there is little information regarding the evolutionary origin and ancestral function of TLR signaling. In Drosophila, members of the Toll-like receptor family are involved in both embryonic development and innate immunity. In C. elegans, a clear immune function of the TLR homolog TOL-1 is controversial and central components of vertebrate TLR signaling including the key adapter protein myeloid differentiation primary response gene 88 (MyD88) and the transcription factor NF-κB are not present. In basal metazoans such as the cnidarians Hydra magnipapillata and Nematostella vectensis, all components of the vertebrate TLR signaling cascade are present, but their role in immunity is unknown. Here, we use a MyD88 loss-of-function approach in Hydra to demonstrate that recognition of bacteria is an ancestral function of TLR signaling and that this process contributes to both host-mediated recolonization by commensal bacteria as well as to defense against bacterial pathogens.

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Language(s): eng - English
 Dates: 2012-11-20
 Publication Status: Published in print
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 Identifiers: DOI: 10.1073/pnas.1213110109
Other: 2965/S 39310
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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proc. Natl. Acad. Sci. U. S. A.
Source Genre: Journal
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Publ. Info: National Academy of Sciences
Pages: - Volume / Issue: 109 (47) Sequence Number: - Start / End Page: 19374 - 19379 Identifier: ISSN: 0027-8424 (print)
ISSN: 1091-6490 (online)
CoNE: /journals/resource/954925427230