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  Retinoid signaling is required for the establishment of a ZPA and for the expression of Hoxb-8, a mediator of ZPA formation.

Lu, H. C., Revelli, J. P., Goering, L., Thaller, C., & Eichele, G. (1997). Retinoid signaling is required for the establishment of a ZPA and for the expression of Hoxb-8, a mediator of ZPA formation. Development, 124(9), 1643-1651.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-503E-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-C4DD-5
Genre: Journal Article

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1577978.pdf (Publisher version), 337KB
 
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 Creators:
Lu, H. C., Author
Revelli, J. P., Author
Goering, L., Author
Thaller, C., Author
Eichele, G.1, Author              
Affiliations:
1Department of Molecular Embryology, Max Planck Institute for Experimental Endocrinology, Max Planck Society, ou_1565140              

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 Abstract: We show that retinoid receptor antagonists applied to the presumptive wing region block the formation of a zone of polarizing activity (ZPA). This suggests a direct relationship between retinoid signaling and the establishment of the ZPA. We provide evidence that the Hox gene, Hoxb-8, is a direct target of retinoid signaling since exogenously applied RA rapidly induces this gene in the absence of protein synthesis and, moreover, retinoid receptor antagonists down-regulate Hoxb-8 expression. In addition, we find that, in the lateral plate mesoderm,the domains of Hoxb-8 expression and of polarizing activity are coextensive. Taken together, these findings support the hypothesis that retinoids are required for the establishment of a ZPA, and that retinoids act, at least in part, through Hoxb-8, a gene associated with ZPA formation (Charite et al., 1994).

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Language(s): eng - English
 Dates: 1997-05
 Publication Status: Published in print
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Title: Development
Source Genre: Journal
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Pages: - Volume / Issue: 124 (9) Sequence Number: - Start / End Page: 1643 - 1651 Identifier: -