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  Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2.

Sharan, S. K., Morimatsu, M., Albrecht, U., Lim, D. S., Regel, E., Dinh, C., et al. (1997). Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature, 386(6627), 804-810. doi:10.1038/386804a0.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-5059-F Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-C4DE-3
Genre: Journal Article

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1577994.pdf (Publisher version), 2MB
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 Creators:
Sharan, S. K., Author
Morimatsu, M., Author
Albrecht, U., Author
Lim, D. S., Author
Regel, E., Author
Dinh, C., Author
Sands, A., Author
Eichele, G.1, Author              
Hasty, P., Author
Bradley, A., Author
Affiliations:
1Department of Molecular Embryology, Max Planck Institute for Experimental Endocrinology, Max Planck Society, ou_1565140              

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 Abstract: Inherited mutations in the human BRCA2 gene cause about half of the cases of early-onset breast cancer. The embryonic expression pattern of the mouse Brca2 gene is now defined and an interaction identified of the Brca2 protein with the DNA-repair protein Rad51. Developmental arrest in Brca2-deficient embryos, their radiation sensitivity, and the association of Brca2 with Rad51 indicate that Brca2 may be an essential cofactor in the Rad51-dependent DNA repair of double-strand breaks, thereby explaining the tumour-suppressor function of Brca2.

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Language(s): eng - English
 Dates: 1997-04-24
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/386804a0
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Title: Nature
Source Genre: Journal
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Pages: - Volume / Issue: 386 (6627) Sequence Number: - Start / End Page: 804 - 810 Identifier: -